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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Perinatal outcomes of renal transplant pregnancies: a 22-year experience at a single tertiary referral center
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Perinatal outcomes of renal transplant pregnancies: a 22-year experience at a single tertiary referral center

机译：肾移植妊娠的围产期结果：单个推荐中心的22年经验

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Background: Renal transplantation not only prolongs survival but also improves quality of life and fertility, particularly in patients with end-stage renal disease. The aim of this study was to evaluate the renal and perinatal outcomes of pregnancy after renal transplantation at a high volume academic tertiary hospital. Methods: Fifty-one renal transplant patients (RTPs) who experienced pregnancy after transplantation and received care at Ege University Hospital between January 1995 and December 2017 were retrospectively identified. Data on demographics, comorbidities, and clinical perinatal outcomes were analyzed. Results: The median age of expectant mothers with renal transplantation was 30.51 +/- 5.28 years (range 23-41). The mean interval between discontinuing birth control methods and the last menstrual period was 22 months. Preeclampsia occurred in six pregnancies (11.5%), and 43 of 52 pregnancies resulted in live births (82.6%). The mean gestational age at birth was 36.35 +/- 2.36 weeks (range: 26-38). A total of 15 births were preterm deliveries (28.8%). Intrauterine growth retardation (IUGR) was detected in four cases. The mean birth weight was 2664.58 +/- 613.99 g (range: 600-3.800 g). Twelve newborns were hospitalized in the neonatal intensive care unit (23%). A significant inverse correlation between birth weight and preconception serum creatinine level was found (p < .001; r = -0.532). An inverse correlation between the interval between transplantation and pregnancy and low postpartum serum creatinine level was established significantly (p < .05; r = -0.331). In addition, an inverse correlation between preconceptional serum creatinine and postpartum serum creatinine in the first year was found statistically significant (p < .001, r = -0.681). Conclusion: Even though pregnancy does not seem to adversely affect renal graft function, risks of perinatal as well as obstetrical complications should not be ignored. Pregnancies in RTPs should be followed closely by a multidisciplinary team of experts to minimize perinatal complications before and during pregnancy.
机译：背景：肾移植不仅延长存活，而且还提高了生命质量和生育能力，特别是在患有终末期肾病的患者中。本研究的目的是评估肾移植在大批量学术高等教育医院肾移植后怀孕的肾和围产期结果。方法：在1995年1月至2017年1月至2017年12月间移植后经历了妊娠期妊娠期妊娠的肾移植患者（RTPS），并于2017年12月在2017年12月期间进行了批评。分析了有关人口统计学，合并症和临床围产期结果的数据。结果：肾移植的预期母亲中位年龄为30.51 +/- 5.28岁（范围23-41）。停止避孕方法和最后一次月经期间的平均间隔为22个月。预口度发生在六次妊娠（11.5％）中发生，52名妊娠中有43名患有活产（82.6％）。出生时的平均胎龄为36.35 +/- 2.36周（范围：26-38）。共有15个出生物是早产（28.8％）。在四个案例中检测到宫内生长延迟（IUGR）。平均出生体重为2664.58 +/- 613.99g（范围：600-3.800g）。 12名新生儿在新生儿重症监护室（23％）住院。发现出生体重和偏见血清肌酐水平之间的显着反相相关（P <.001; r = -0.532）。显着建立移植与妊娠和低产后血清肌酐水平之间的间隔之间的反比相关性（P <.05; r = -0.331）。此外，在第一年中，先进血清肌酐与产后血清肌酐之间的反比相关性统计学意义（p <.001，r = -0.681）。结论：即使妊娠似乎没有对肾移植功能产生不利影响，不应忽视围产期的风险以及产科并发症。 RTPS的怀孕应由多学科专家团队紧密遵循，以最大限度地减少怀孕之前和期间的围产期并发症。

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