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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >What is the optimal duration of oral misoprostol treatment for cervical ripening?
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What is the optimal duration of oral misoprostol treatment for cervical ripening?

机译：宫颈成熟的口服误解源治疗的最佳持续时间是多少？

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Objectives: To evaluate the number of misoprostol tablets needed to obtain a Bishop score (BS)6 or a significant cervical change (2 points in BS) during cervical ripening.Methods: Retrospective study of women with term singleton pregnancies and a BS<6 taking oral misoprostol (20g first 2 doses followed by 40g every 2h) for cervical ripening.Results: We included 400 women, 72% nulliparous, mean age of 31.35.9 years and 70% with a baseline BS2. During cervical ripening, 61 (15.3%) achieved a BS6 and 205 (51.3%) a significant change in BS. The incremental risk to achieve a BS6 after 4 tablets was low (+3.25%) with an incremental probability of +12.75% for painful uterine contractions and +0.5% for abnormal fetal tracing (AFT). The incremental probability to achieve a significant change in BS after 7 tablets was low (+2.0%). 24.3% women delivered by cesarean section which likelihood significantly increased with maternal age <35 years, BMI30, nulliparity, AFT, and baseline BS2.Conclusions: The marginal benefit of giving more than 7 misoprostol tablets (14h) during cervical ripening is very low.
机译：目的：为了评估获得主教得分（BS）6所需的误狂片剂的数量或颈椎成熟期间的显着颈椎发生（BS中的2分）。方法：术语单身妊娠术语和BS <6患者的妇女的回顾性研究口服误解源（20g前2剂，每2克，每2小时为40g），用于颈椎成熟。结果：我们包括400名女性，72％的少数，平均年龄为31.35.9岁，70％，基线BS2为70％。在颈椎成熟期间，61（15.3％）达到BS6和205（51.3％）BS的显着变化。在4片剂后实现BS6的增量风险低（+ 3.25％），疼痛子宫收缩的增量概率为+ 12.75％，胎儿追踪异常+ 0.5％（AFT）。在7片剂后在BS达到显着变化的增量概率低（+ 2.0％）。 24.3％的妇女剖腹产妇女，妇女年龄的可能性显着增加<35岁，BMI30，无污垢性，AFT和基线BS2。结论：在宫颈成熟过程中给予超过7个误解片剂（14H）的边际益处非常低。

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