...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Vitamin D and corticotropin-releasing hormone in term and preterm birth: potential contributions to preterm labor and birth outcome
【24h】

Vitamin D and corticotropin-releasing hormone in term and preterm birth: potential contributions to preterm labor and birth outcome

机译：维生素D和皮质甾醇释放激素，并出生的早产：对早产和出生结果的潜在贡献

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Poor maternal vitamin D status and elevated circulating corticotropin-releasing hormone (CRH) are associated with preterm birth. It is not known if these risk factors are independent or interrelated. Both are associated with inflammation. Methods: We measured maternal circulating 25-hydroxyvitamin D (25-OH-D) and CRH from 97 samples collected from 15 early-preterm, 31 late-preterm, 21 early-term, and 30 term births. The potential involvement of vitamin D in the regulation of inflammation was evaluated by Q-PCR in human uterine smooth muscle (UTSM) cell line. Results: Maternal 25-OH-D was lowest in early-preterm births (22.9±4.2 ng/ml versus 34.4± 1.4 ng/ml; p = .029). Circulating CRH was high in early-preterm births (397±30pg/ml). Late-preterm (304± 13 pg/ml) and early-term births (347± 17 pg/ml) were not different from term births (367 ± 19 pg/ml), after accounting for gestational age. Maternal circulating 25-OH-D and CRH were not associated in term births. In preterm births, 25-OH-D below 30 ng/ml was associated with higher CRH. Vitamin D treatment of UTSM significantly reduced mRNA for leptin and IL-6 receptors. Deletion of vitamin D receptor from UTSM promoted the expression of the cox2 inflammatory marker. Conclusion: Early-preterm birth showed a syndrome of high maternal CRH and low vitamin D status.
机译：背景：粮食体维生素D状态可差，循环皮质培素释放激素（CRH）与早产有关。如果这些风险因素是独立或相互关联的，则不知道。两者都与炎症有关。方法：我们测量母体循环25-羟基vitamind（25-OH-D）和CRH从15次早产，31晚早期，21例早期和30项初期收集的97个样品。通过Q-PCR在人子宫平滑肌（UTSM）细胞系中的Q-PCR评估维生素D在炎症调节中的潜在参与。结果：早产出生的母体25-OH-D最低（22.9±4.2ng / ml与34.4±1.4 ng / ml; p = .029）。早产的循环CRH高（397±30pg / ml）。在叙事年龄核算后，晚期早产（304±13pg / ml）和早期出生（347±17 pg / ml）与术语出生（367±19 pg / ml）不同。母亲循环25-OH-D和CRH在术语出生中没有相关。在早产出生时，低于30ng / ml的25-OH-D与较高的CRH相关。维生素D治疗UTSM的瘦蛋白和IL-6受体的mRNA显着降低。从UTSM缺失维生素D受体促进了COX2炎症标志物的表达。结论：早产出生出现高母体CRH和低维生素D状态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号