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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Does meperidine analgesia affect the incidence of obstetric lacerations at vaginal delivery?
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Does meperidine analgesia affect the incidence of obstetric lacerations at vaginal delivery?

机译：Meperidine镇痛是否影响了阴道递送的产科撕裂的发生率？

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Purpose: To study whether meperidine analgesia affects the incidence of obstetric lacerations at normal vaginal deliveries.Materials and methods: A retrospective cohort study of all women with term vertex singleton pregnancies, who underwent normal vaginal deliveries, in a single tertiary hospital, between 2011 and 2015, was performed. The incidence of various obstetric lacerations was compared between deliveries with meperidine analgesia and deliveries with no analgesia. Deliveries with epidural analgesia and instrumental deliveries were excluded. An intravenous infusion of 75mg of meperidine was administered together with 25mg of promethazine. A multivariate logistic regression analysis was performed to assess the association between meperidine analgesia and obstetric lacerations, after controlling for confounders.Results: Overall, 5227 (91.8%) deliveries with no analgesia and 466 (8.1%) deliveries with meperidine analgesia were included. Meperidine analgesia was associated with a decreased risk of first- and second-degree perineal lacerations (adjusted OR=0.63, 95% CI=0.49-0.81), and a decreased risk of any suturing (adjusted OR=0.73, 95% CI=0.59-0.91), after controlling for confounders. Meperidine analgesia did not affect the risk of severe perineal lacerations or episiotomies.Conclusion: Meperidine analgesia may have a protective effect against first- and second-degree perineal lacerations.
机译：目的：研究哌替啶镇痛是否会影响正常阴道递送的产科撕裂的发生率。材料和方法：一项术语的重新调整队列队列，患有术语术语患者，在2011年间，在单个第三节医院进行正常阴道递送2015年，进行了。将各种产科撕裂性的发病率进行比较，与哌替啶镇痛和没有镇痛的递送。排除了硬膜外镇痛和器具交付的交货。将75mg哌替啶的静脉输注在一起与25mg丙嗪一起施用。进行多元逻辑回归分析以评估近哌啶镇痛和产科撕裂之间的关联，在控制混淆后。结果：总体而言，5227（91.8％）含有镇痛和466（8.1％）与哌替啶镇痛的递送。 Meperidine镇痛与第一和第二程度的阴部撕裂的风险降低（调节或= 0.63,95％CI = 0.49-0.81），以及任何缝合的风险降低（调节或= 0.73,95％CI = 0.59 -0.91），在控制混乱之后。 Meperidine镇痛不会影响严重的会阴撕裂或ePiSiocomies的风险。结论：哌啶镇痛可能对第一和二级的阴部撕裂有保护作用。

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