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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >The recurrence risk of group B Streptococcus in consecutive deliveries
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The recurrence risk of group B Streptococcus in consecutive deliveries

机译：连续交付中B组链球菌的复发风险

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Background: Group B streptococcus (GBS) is a significant cause of neonatal morbidity and mortality. GBS maternal colonization status was found to be transient, intermittent, or chronic and screening during each subsequent pregnancy was advised. Recent studies showed that GBS colonization rate was higher among women with history of GBS positive in prior pregnancy. Objective: To establish the cumulative risk of group B streptococcus (GBS) colonization in consecutive subsequent term deliveries as referred to the first delivery GBS colonization status. Study design: A retrospective cohort study, based on a validated computerized database at a tertiary single center between the years 2005-2016. Pregnant women preform vaginal-rectal culture at 35-37 weeks of gestation. We analyzed records of term primiparas women that had records of up to three additional term consecutive deliveries and GBS colonization status. Results: 8641 primiparas met inclusion criteria; 3972 (46.0%), 993 (11.5%), and 243 (2.8%) had second, third, and fourth consecutive deliveries with recorded GBS status respectively. The overall colonization rate for primiparas was 28.4%. The cumulative rates and cumulative risks of repeated GBS positive colonization at the second, third and fourth term consecutive deliveries were 62.0%, 6.93 (95% CI 5.96-8.06), 68.0%, 5.05 (95% CI, 3.67-6.93), and 66.1%, 2.96 (95% CI, 1.54-5.68), respectively. Notably, after a negative GBS colonization in the first, second, and third repeated deliveries, the rate and cumulative risk of GBS positive in each consecutive delivery was significantly lower: 18.2%, 0.14, (95% CI 0.12-0.17), 19.4%, 0.21 (95% CI 0.15-0.28), and 21%, 0.26 (95% CI 0.13-0.51) for the second, third, and fourth consecutive deliveries, respectively. Conclusion: GBS colonization status at the time of first pregnancy is a milestone for the colonization risk in subsequent term deliveries. This risk evaluation may influence the decision-making process for future screening and intrapartum antibiotic prophylaxis for term consecutive deliveries.
机译：背景：B组链球菌（GBS）是新生儿发病率和死亡率的重要原因。在每个后续怀孕期间发现GBS母体定殖状况是瞬态，间歇性的，间歇性或慢性和筛选。最近的研究表明，在先前怀孕的GBS阳性患者中，GBS殖民化率较高。目的：在第一次递送GBS定子地位，建立连续后续术语交付中B组链球菌（GBS）定植的累积风险。研究设计：基于2005 - 2016年之间的第三级单中心的经过验证的计算机化数据库，研究了一个回顾性队列研究。孕妇在妊娠35-37周的35-37周之前预成型阴道培养。我们分析了术语初级孕期妇女的记录，其中有最多三个额外的连续交付和GBS定植身份的记录。结果：8641 Priparas符合纳入标准; 3972（46.0％），993（11.5％）和243名（2.8％）分别具有录制的GBS状态，分别具有第二，第三，第四和第四个连续交付。 Priparas的总结率为28.4％。第二次，第三期和第四术语连续交付中重复GBS阳性定植的累积率和累积风险为62.0％，6.93（95％CI 5.96-8.06），68.0％，5.05（95％CI，3.67-6.93），和分别为66.1％，2.96（95％CI，1.54-5.68）。值得注意的是，在第一，第二和第三次重复递送中的阴性GBS殖民化之后，在每次连续递送中的GBS阳性的速率和累积风险显着降低：18.2％，0.14，（95％CI 0.12-0.17），19.4％ ，分别为0.21（95％CI 0.15-0.28），21％，0.26（95％CI 0.13-0.51），分别为第二，第三，第四个连续交付。结论：第一次怀孕时的GBS定植状态是随后术语交付中的殖民风险的里程碑。这种风险评估可能会影响未来筛查和癌药物抗生素预防的决策过程，连续递送。

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