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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Peri-conceptional progesterone treatment in women with unexplained recurrent miscarriage: a randomized double-blind placebo-controlled trial
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Peri-conceptional progesterone treatment in women with unexplained recurrent miscarriage: a randomized double-blind placebo-controlled trial

机译：妇女孕妇孕酮治疗患有无法解释的复发性流产的妇女：随机双盲安慰剂对照试验

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Objective: The current study aims to evaluate the effect of peri-conceptional progesterone started early in the luteal phase before confirmation of pregnancy in preventing miscarriage in women with history of unexplained recurrent miscarriage (RM).Materials and methods: The current study was a randomized double-blind controlled trial (NCT01608347) conducted at Assiut Women's Health Hospital from 2012 through 2015 included patients of unexplained RM. Participants were randomly assigned to receive either 400mg progesterone pessaries or placebo twice daily, started in the luteal phase and continued after a positive pregnancy test till 28weeks of gestation. The main study outcome was the miscarriage rate.Results: Seven hundred women were enrolled (n=350 in each group). The miscarriage rate was significantly lower in progesterone group (12.4 versus 23.3% in the placebo group, p=0.001). There was significant improvement in rate of pregnancy continuation beyond 20weeks as well as the live birth rate in the progesterone group in comparison to placebo group (87.6 versus 76.7% and 91.6 versus 77.4%, respectively, p<0.05).Conclusions: Progesterone is more effective than placebo in reducing the risk of miscarriage if administered in the luteal phase of the cycle, before confirmation of pregnancy in women with history of unexplained RM.
机译：目的：目前的研究旨在评估脑胰岛素早期在患者早期开始于患者开始的患者，在确认怀孕中，以防止具有无法解释的复发流产（RM）的妇女流产。材料和方法：目前的研究是随机的从2012年到2015年到2015年通过2012年至2015年的Assiut女性健康医院进行双盲控制试验（NCT01608347）包括未解释的RM患者。随机分配参与者每天两次接受400毫克孕酮佩斯 - 或安慰剂，在肺癌中开始，持续妊娠试验到28周的妊娠。主要研究结果是流产率。结果：七百名女性注册（每组N = 350）。孕酮基团中流产率显着降低（安慰剂组12.4与23.3％，P = 0.001）。与安慰剂组相比，妊娠期持续超过20周的妊娠延续率显着提高（87.6与76.7％和91.6与77.4％，P <0.05）。结论：黄体酮更多如果在循环缺失阶段施用患有疾病的患者，在患有未解释的RM历史的妇女的妊娠之前，减少流产风险的安慰剂有效。

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