• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Comparative Neurology >Kolliker-Fuse GABAergic and glutamatergic neurons project to distinct targets
【24h】

Kolliker-Fuse GABAergic and glutamatergic neurons project to distinct targets

机译：Kolliker-Fuse-Fuse Gabaergic和谷氨酸神经元项目以不同的目标

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Kolliker-Fuse nucleus (KF) is known primarily for its respiratory function as the "pneumotaxic center" or 'pontine respiratory group." Considered part of the parabrachial (PB) complex, KF contains glutamatergic neurons that project to respiratory-related targets in the medulla and spinal cord (Yokota, Oka, Tsumori, Nakamura, & Yasui, 2007). Here we describe an unexpected population of neurons in the caudal KF and adjacent lateral crescent subnucleus (PBlc), which are -aminobutyric acid (GABA)ergic and have an entirely different pattern of projections than glutamatergic KF neurons. First, immunofluorescence, in situ hybridization, and Cre-reporter labeling revealed that many of these GABAergic neurons express FoxP2 in both rats and mice. Next, using Cre-dependent axonal tracing in Vgat-IRES-Cre and Vglut2-IRES-Cre mice, we identified different projection patterns from GABAergic and glutamatergic neurons in this region. GABAergic neurons in KF and PBlc project heavily and almost exclusively to trigeminal sensory nuclei, with minimal projections to cardiorespiratory nuclei in the brainstem, and none to the spinal cord. In contrast, glutamatergic KF neurons project heavily to the autonomic, respiratory, and motor regions of the medulla and spinal cord previously identified as efferent targets mediating KF cardiorespiratory effects. These findings identify a novel, GABAergic subpopulation of KF/PB neurons with a distinct efferent projection pattern targeting the brainstem trigeminal sensory system. Rather than regulating breathing, we propose that these neurons influence vibrissal sensorimotor function.
机译：Kolliker-Fuse核（KF）主要是因为其呼吸功能为“肺炎症中心”或“粪便呼吸组”。“涉及Parabrachial（Pb）复合物的一部分，KF含有谷氨酰胺神经元，该谷氨酸神经元涉及呼吸相关的目标髓质和脊髓（Yokota，Oka，Tsumori，Nakamura，＆Yasui，2007）。在这里，我们描述了尾部KF和相邻的侧颈氨核（PBLC）中的神经元的意外群体，它们是 - 氨基丁酸（GABA）Ergic并且具有比谷氨酸克拉内酯KF神经元的完全不同的投影模式。首先，免疫荧光，原位杂交和Cre-Reporter标记揭示了许多这些加布的神经元在大鼠和小鼠中表达Foxp2。接下来，使用CRE依赖性轴突追踪VGAT-IRES-CRE和VGLUT2-IRES-CRE小鼠，我们确定了来自该地区的加布生物和谷氨酸神经元的不同投影模式。KF和PBLC中的加巴能神经元严重和几乎被公开通过性地进行三叉核，脑干中的心肺核突出最小，没有脊髓。相比之下，谷氨酸谷氨酸KF神经元对髓质和脊髓的自主主义，呼吸和电机区域统一，以前鉴定为介导KF心肺效果的迁移靶点。这些发现鉴定了KF / PB神经元的新型胃肠杆菌亚群，具有靶向脑干三际感觉系统的不同的散文投影模式。我们提出这些神经元影响vibriassisimotor功能而不是调节呼吸。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号