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首页> 外文期刊>The Journal of Comparative Neurology >Distribution and female reproductive state differences in orexigenic and anorexigenic neurons in the brain of the mouth brooding African cichlid fish, Astatotilapia burtoni
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Distribution and female reproductive state differences in orexigenic and anorexigenic neurons in the brain of the mouth brooding African cichlid fish, Astatotilapia burtoni

机译：口腔脑袋中颅脑和厌氧神经元的分布与雌性生殖状态差异，非洲慈鲷鱼，Astatotilapia Burtoni

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Integration of reproduction and metabolism is necessary for species survival. While the neural circuits controlling energy homeostasis are well-characterized, the signals controlling the relay of nutritional information to the reproductive axis are less understood. The cichlid fish Astatotilapia burtoni is ideal for studying the neural regulation of feeding and reproduction because females cycle between a feeding gravid state and a period of forced starvation while they brood developing young inside their mouths. To test the hypothesis that candidate neuropeptide-containing neurons known to be involved in feeding and energy homeostasis in mammals show conserved distribution patterns, we performed immunohistochemistry and in situ hybridization to localize appetite-stimulating (neuropeptide Y, NPY; agouti-related protein, AGRP) and appetite-inhibiting (cocaine and amphetamine-regulated transcript, CART; pro-opiomelanocortin, pomc1a) neurons in the brain. NPY, AGRP, CART, and pomc1a somata showed distribution patterns similar to other teleosts, which included localization to the lateral tuberal nucleus (NLT), the putative homolog of the mammalian arcuate nucleus. Gravid females also had larger NPY and AGRP neurons in the NLT compared to brooding females, but brooding females had larger pomc1a neurons compared to gravid females. Hypothalamic agrp mRNA levels were also higher in gravid compared to brooding females. Thus, larger appetite-stimulating neurons (NPY, AGRP) likely promote feeding while females are gravid, while larger pomc1a neurons may act as a signal to inhibit food intake during mouth brooding. Collectively, our data suggest a potential role for NPY, AGRP, POMC, and CART in regulating energetic status in A. burtoni females during varying metabolic and reproductive demands.
机译：物种生存是必要的生殖和新陈代谢的整合。虽然控制能量稳态的神经电路是良好的表征，但是控制将营养信息中继到生殖轴的信号的信号不太了解。 CICHLID FISH ASTATOTILAPIA BURTONI是研究喂养和繁殖神经调节的理想选择，因为饲养妊娠末期与强迫饥饿期之间的女性循环，同时它们在嘴里养育年轻人。为了测试候选含有含有神经肽的神经元的假设，该神经元在哺乳动物中涉及哺乳动物的喂养和能量稳态，我们进行了保守的分布模式，我们对本地化食欲刺激（Neuropeptide Y，NPy; agouti相关蛋白质，所述免疫组织化学和原位杂交表现出免疫组织化学和刺激性杂交; Aguti相关的蛋白质，进行免疫组化和原位杂交。 ）和食欲抑制（可卡因和疗法调节的转录物，推车;脑中的POMC1A）神经元。 NPY，AGRP，推车和POMC1A SOMATA显示出类似于其他EXTEROSTS的分布模式，其中包括对侧核细胞核（NLT）的定位，哺乳动物弧形核的推定同源物。与育雏女性相比，妊娠女性在NLT中也具有较大的NPY和Agrp神经元，但与妊娠女性相比，育雏女性具有较大的POMC1A神经元。与沉重的女性相比，妊娠的下丘脑AGRP mRNA水平也更高。因此，较大的食欲刺激神经元（NPY，AGRP）可能促进喂养，而雌性是妊娠，而较大的POMC1A神经元可以作为抑制口腔育雏期间抑制食物摄入的信号。统称，我们的数据表明，在不同的代谢和生殖要求期间，NPY，AGRP，POMC和CART在对Burtoni女性中调节能量状态的潜在作用。

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