Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial

Mehta Rajendra H.; Van Diepen Sean; Meza James; Bokesch Paula; Leimberger Jeffrey D.; Tourt-Uhlig Sandra; Swartz Merri; Parrotta Jodi; Jankowich Rachael; Hay Douglas; Harrison Robert W.; Fremes Stephen; Goodman Shaun G.; Luber John; Toller Wolfgang; Heringlake Matthias; Anstrom Kevin J.; Levy Jerrold H.; Harrington Robert A.; Alexander John H.

首页> 外文期刊>The American heart journal >Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial

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Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial

机译：左咪丹丹患者患有左心室收缩功能障碍的心肺手术旁路：左心室收缩功能障碍患者的左索亚丹丹的基本原理和研究设计需要心肺手术，需要心肺手术（Levo-CTS）试验

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Background Low cardiac output syndrome is associated with increased mortality and occurs in 3% to 14% of patients undergoing cardiac surgery on cardiopulmonary bypass (CPB). Levosimendan, a novel calcium sensitizer and K-ATP channel activator with inotropic, vasodilatory, and cardioprotective properties, has shown significant promise in reducing the incidence of low cardiac output syndrome and related adverse outcomes in patients undergoing cardiac surgery on CPB.

机译：背景技术较低的心脏输出综合征与增加的死亡率有关，并且发生在3％至14％的患者上进行心肺手术（CPB）。 Levosimendan，一种新型钙敏化剂和具有肌室，血管舒张和心脏保护性的K-ATP通道活化剂，对降低CPB心脏手术患者的低心输出综合征及相关不良结果的显着承诺。

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《The American heart journal》 |2016年第2016期|共10页
作者
Mehta Rajendra H.; Van Diepen Sean; Meza James; Bokesch Paula; Leimberger Jeffrey D.; Tourt-Uhlig Sandra; Swartz Merri; Parrotta Jodi; Jankowich Rachael; Hay Douglas; Harrison Robert W.; Fremes Stephen; Goodman Shaun G.; Luber John; Toller Wolfgang; Heringlake Matthias; Anstrom Kevin J.; Levy Jerrold H.; Harrington Robert A.; Alexander John H.;
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作者单位

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Univ Alberta Canadian VIGOUR Ctr Edmonton AB Canada;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Tenax Therapeut Morrisville NC USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Univ Alberta Canadian VIGOUR Ctr Edmonton AB Canada;

Tenax Therapeut Morrisville NC USA;

Tenax Therapeut Morrisville NC USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Univ Alberta Canadian VIGOUR Ctr Edmonton AB Canada;

Univ Alberta Canadian VIGOUR Ctr Edmonton AB Canada;

Franciscan Hlth Syst Tacoma WA USA;

Graz Univ Graz Austria;

Univ Lubeck Lubeck Germany;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

Stanford Univ Sch Med Stanford CA 94305 USA;

Duke Univ Sch Med Duke Clin Res Inst Durham NC USA;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
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1. Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial [J] . Mehta Rajendra H., Van Diepen Sean, Meza James, The American heart journal . 2016,第期

机译：左咪丹丹患者患有左心室收缩功能障碍的心肺手术旁路：左心室收缩功能障碍患者的左索亚丹丹的基本原理和研究设计需要心肺手术，需要心肺手术（Levo-CTS）试验
2. GW29-e1895 Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery: a meta-analysis and trial sequential analysis of randomized trials [J] . Zhenhua Xing, Junyu Pei Journal of the American College of Cardiology . 2018,第16期

机译：GW29-E1895左索亚丹患者患有心脏手术的左心室功能障碍：随机试验的荟萃分析和试验顺序分析
3. Preconditioning with levosimendan reduces postoperative low cardiac output in moderate-severe systolic dysfunction patients who will undergo elective coronary artery bypass graft surgery: a cost-effective strategy [J] . Juan José Jiménez-Rivera, Andrea álvarez-Castillo, Jorge Ferrer-Rodríguez, Journal of Cardiothoracic Surgery . 2020,第1期

机译：预处理与左索亚芬丹在中度严重的收缩功能障碍患者中降低术后低心输出，该患者将接受选修冠状动脉旁路移植手术：一种经济高效的策略
4. Single Beat Estimation Of Right Ventricular End-systolic Elastance In Patients Undergoing Left Ventricular Assist Device Implantation [C] . Mandarino W.A., Morita S., Kormos R.L., Engineering in Medicine and Biology Society, 1991. Vol.13: 1991., Proceedings of the Annual International Conference of the IEEE . 1991

机译：左室辅助装置植入患者右室收缩末期弹性的单搏估计
5. Pharmacological and Clinical Factors Associated with Thrombosis in Pediatric Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass. [D] . Manlhiot, Cedric. 2015

机译：小儿接受心肺旁路心脏手术的患者中与血栓形成相关的药理和临床因素。
6. Preoperative levosimendan decreases mortality and the development of low cardiac output in high-risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass [O] . Ricardo Levin, Marcela Degrange, Carlos Del Mazo, 2012

机译：术前左西孟旦可降低严重左心功能不全的高危患者行冠状动脉搭桥术并进行体外循环从而降低死亡率并降低心输出量
7. Perioperative Use of Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery on Cardiopulmonary Bypass [O] . Gamal Lotfy Abd Elrahman, Mostafa Mohammed Sabra, Amr Soliman Abd Elmageed, 2019

机译：围手术期使用左心眼丹患者患者左心室收缩功能障碍，在心肺手术中进行心肺手术
8. Heart Failure: Evaluation and Care of Patients with Left-Ventricular Systolic Dysfunction. Clinical Practice Guideline No. 11; Heart Failure: Management of Patients with Left-Ventricular Systolic Dysfunction. Quick Reference Guide for Clinicians No. 11; Living with Heart Disease: Is It Heart Failure. Patient and Family Guide [R] . 1994

机译：心力衰竭：左心室收缩功能障碍患者的评估和护理。临床实践指南第11号;心力衰竭：左心室收缩功能障碍患者的治疗。临床医生快速参考指南第11号;与心脏病共存：是心衰吗？患者和家庭指南

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