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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Oxcarbazepine-Induced Cutaneous Reaction in a Female of Mexican Ancestry
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Oxcarbazepine-Induced Cutaneous Reaction in a Female of Mexican Ancestry

机译：Oxcarbazepine诱导的墨西哥血统女性皮肤反应

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Objectives: To report an oxcarbazepine (OXC)-induced cutaneous reaction in a female of Mexican ancestry. Case Summary: A 60-year-old female of Mexican ancestry presented to clinic with a diffuse morbilliform rash, with erythema and eruptions of papules/pustules concentrated on her neck and torso. The rash appeared I week following the initiation of OXC for trigeminal neuralgia. Initially, the correlation between the reaction and initiation of OXC was not recognized by the provider. OXC was continued for a total of 4 weeks and several medical encounters transpired in the interim. Supportive therapy, in the form of oral antihistamines and oral/topical corticosteroids, failed to resolve the rash. A clinical pharmacist prompted the discontinuation of OXC due to suspicion that it incited the adverse reaction. Oral corticosteroid therapy was initiated and tapered over 2 weeks, with rash dissipation occurring in I month. Discussion: The association of OXC with the cutaneous eruption was classified as "probable" based on the Naranjo Scale. While financial resources were not available to perform genetic testing, it may be possible that the genetic status of this patient lent itself to greater potential for cutaneous reactions with OXC. Further research is needed to determine whether pharmacogenetic variables affiliated with pre-Columbian lineage may predispose individuals to specific adverse drug reactions. Conclusion: As regional genotypes disperse globally, it is imperative that clinicians are cognizant of risks regarding genetically implicated adverse drug reactions. While information is limited for certain ethnicities, it is essential that providers diligently monitor all populations for reactions characteristic to specific medications.
机译：目的：在墨西哥血统的女性中报告牛毒碱（OXC）诱导的皮肤反应。案例摘要：一位60岁的墨西哥血统女性患有弥漫性Morbilliform皮疹的诊所，红斑和丘疹的喷发浓缩在她的颈部和躯干上。在发起一次三叉神经痛的OXC后，皮疹出现了一周。最初，提供者无法识别出反应和OXC的反应与发起之间的相关性。 OXC共持续4周，几个医疗遭遇在临时临时。支持性治疗，以口服抗组胺药和口腔/局部皮质类固醇的形式未能解决皮疹。临床药剂师促使由于怀疑它引起的不良反应而停止oxc。口腔皮质类固醇治疗在2周内开始并逐渐逐渐变化，在I个月内发生皮疹耗散。讨论：基于Naranjo规模的oxc与皮肤喷发的关系被归类为“可能”。虽然财务资源无法进行遗传检测，但该患者的遗传状态可能借给XORC的皮肤反应的潜力。需要进一步的研究来确定与哥伦比亚血管前谱系的药物发生变量是否可以使个体倾向于特异性不良药物反应。结论：作为全球分散的区域基因型，临床医生必须认识到基因牵种不良药物反应的风险。虽然信息受到某些种族的限制，但提供者必须孜孜不机地监测所有群体的特征对特定药物的反应。

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