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首页> 外文期刊>The Journal of Nutritional Biochemistry >Response to the photoperiod in the white and brown adipose tissues of Fischer 344 rats fed a standard or cafeteria diet
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Response to the photoperiod in the white and brown adipose tissues of Fischer 344 rats fed a standard or cafeteria diet

机译：响应Fischer 344大鼠的白色和棕色脂肪组织中的光周期，喂养标准或自助餐厅饮食

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Researchers are identifying new factors that contribute to the obesity epidemic, with changes in the photoperiod as one promising risk factor. To study the influence of the photoperiod on adipose tissue, Fischer 344 rats were treated for 14 weeks with a long day (18 h light:6 h dark; LD) or a short day (6 h light:18 h dark; SD) and fed a standard diet (STD). Biometric measures, postprandial plasmatic parameters, gene expression in the retroperitoneal white adipose tissue (RWAT) and brown adipose tissue (BAT) and histology of the RWAT were analyzed. A second experiment with the same conditions and analysis was performed for 11 weeks with rats fed a cafeteria diet (CAF). In the STD experiment, the SD increased triglycerides and showed a tendency to reduce fat compared to the LD. In the RWAT, genes implicated in adipogenesis, lipogenesis and lipolysis were down-regulated, and the histological results showed a higher percentage of small adipocytes in the SD without changes in their total number. In the CAF experiment, lipogenesis and adipogenesis gene expression was increased in the SD, while adipocytes were smaller and their number increased. Both experiments showed in the SD a decrease in the BAT expression of lipid uptake and beta-oxidation genes, while only the STD additionally showed a reduction in Ucp1 expression. In conclusion, the RWAT morphology and the expression of key genes for lipid metabolism in RWAT and BAT were influenced by the photoperiod; however, the changes observed in the RWAT were different depending on the diet. (C) 2019 The Authors. Published by Elsevier Inc.
机译：研究人员正在识别有助于肥胖流行病的新因素，以PhotoCeriod变化为一个有希望的危险因素。为了研究光周期对脂肪组织的影响，漫长的一天（18小时光：6小时黑暗）或短日（6小时光：18小时黑暗; 18小时黑暗; 18小时）和联合标准饮食（STD）。分析了生物识别措施，对后腹膜脂肪组织（RWAT）和棕色脂肪组织（蝙蝠）和褐色脂肪组织（蝙蝠）和rwat的组织学的基因表达。用喂养自助餐厅饮食（CAF）的大鼠进行具有相同条件和分析的第二种实验。在STD实验中，SD增加了甘油三酯，并显示与LD相比减少脂肪的趋势。在RWAT中，将涉及脂肪发生，脂肪生成和脂肪分解的基因进行了下调，组织学结果在SD中显示出较高百分比的小脂肪细胞，而不改变它们的总数。在CAF实验中，SD中的脂肪生成和脂肪生成基因表达增加，而脂肪细胞较小，并且它们的数量增加。两个实验在SD中显示出脂质摄取和β-氧化基因的BAT表达的降低，而STD另外表现出UCP1表达的降低。总之，rwat形态和乳脂代谢对脂质代谢的关键基因的表达受到光周期的影响;然而，在rwat中观察到的变化取决于饮食。 （c）2019年作者。 elsevier公司发布

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