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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice
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Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

机译：运动和膳食蛋白质来源对肥胖小鼠肥胖和胰岛素敏感性的影响

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Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of exercise vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose (HF/HS) diet to induce obesity and then either maintained on the HF/HS or shifted to low-fat (LF) diets containing either salmon or entrecote. For each diet, half of the animals exercised voluntarily for 8 weeks. We determined body composition, glucose tolerance, insulin sensitivity and hepatic triacylglycerol levels. The microbiota composition in cecal and fecal samples was analyzed using 16S ribosomal RNA gene amplicon sequencing. Voluntary exercise improved insulin sensitivity but did not improve glucose tolerance. Voluntary exercise did not reduce adiposity in mice maintained on an HF/HS diet but enhanced LF-induced reduction in adiposity. Hepatic triacylglycerol levels were reduced by voluntary exercise in LF- but not HF/HS-fed mice. Voluntary exercise induced shifts in the cecal and fecal microbiota composition and functional potential in mice fed LF or HF/HS diets. Whereas voluntary exercise improved insulin sensitivity, a switch to an LF diet was the most important factor related to body weight and fat mass reduction. (C) 2019 The Authors. Published by Elsevier Inc.
机译：通常假设低脂肪饮食和运动可以改善与肥胖有关的代谢功能障碍，但争论运动与饮食变更的重要性。将雄性C57BL / 6J小鼠喂养高脂肪/高蔗糖（HF / HS）饮食以诱导肥胖，然后保持在HF / HS上或移至含有三文鱼或entrecote的低脂肪（LF）饮食。每次饮食，一半的动物自愿行使8周。我们确定了身体成分，葡萄糖耐量，胰岛素敏感性和肝三酰基甘油水平。使用16S核糖体RNA基因扩增子测序分析盲肠和粪便样品中的微生物群组合物。自愿运动改善胰岛素敏感性，但没有提高葡萄糖耐受性。自愿运动并未将小鼠的肥胖降低，但在HF / HS饮食中维持但增强了LF诱导的肥胖降低。通过LF-但不是HF / HS-FED小鼠的自愿运动减少了肝三酰基甘油水平。自愿运动诱导在肠道和粪便微生物群组合物中的转变和喂养LF或HF / HS饮食的小鼠的功能势。虽然自愿运动改善了胰岛素敏感性，但是，对LF饮食的开关是与体重和脂肪量减少相关的最重要因素。 （c）2019年作者。 elsevier公司发布

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