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首页> 外文期刊>The Journal of Nutritional Biochemistry >Gestational caloric restriction improves redox homeostasis parameters in the brain of Wistar rats: a screening from birth to adulthood
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Gestational caloric restriction improves redox homeostasis parameters in the brain of Wistar rats: a screening from birth to adulthood

机译：妊娠热量限制改善Wistar大鼠脑中的氧化还原稳态参数：从出生到成年期的筛查

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摘要

Caloric restriction (CR) improves health and life span in animal models. Although CR effects in adult life are well described, little is known about effects on offspring when applied during gestation. Pregnancy is a remarkable period of life, alterations in this stage lead to lifelong consequences, some of which, associated to redox unbalance. Furthermore, gestational overweight is a growing issue that can lead to detrimental outcomes. To address this issue, we divided pregnant rats into control (ad libitum food) and CR groups, which received 20% less food than control. Micronutrients consumption was equalized between groups by oral gavage. Cerebellum, prefrontal cortex, hippocampus, and hypothalamus were evaluated on post-natal day (PND) 0, 7, 21, and 60. We observed increased oxidants content on PNDO in all brain structures, except for the cerebellum. Key enzymatic antioxidant defenses showed decreased activity on PNDO. Interestingly, on PND60, we observed a positive modulation of most antioxidant enzymes, especially on the prefrontal cortex and hippocampus. Non-enzymatic antioxidant defenses were decreased at birth and increased during development and adult age. Lipid peroxidation was increased at birth on most structures, and the effect was abolished thereafter. In the prefrontal cortex, lipid peroxidation was unaltered at birth and diminished thereafter, while protein oxidation was increased on PNDO and decreased on PND60. Protein oxidation was also decreased in the cerebellum at adult age. Our results shown controlled gestational CR to improve antioxidant defenses and protect offspring's brain from oxidative stress, especially in adulthood, as a result of developmental metabolic programming. (C) 2019 Elsevier Inc. All rights reserved.
机译：热量限制（CR）改善了动物模型中的健康和寿命。尽管在成人寿命中的CR效应很好地描述，但在妊娠期间施加时对后代的影响很少。怀孕是一种显着的生活时期，这个阶段的改变导致终身后果，其中一些与氧化还原不平衡相关。此外，妊娠超重是一种不断增长的问题，可能导致不利的结果。为了解决这个问题，我们将怀孕的大鼠分为控制（可怕的食物）和Cr组，其食物减少20％。通过口服饲养在组之间均衡微量营养素。在产后日（PND）0,7,21和60上评估了小脑，前额叶皮质，海马和下丘脑。除了小脑外，我们观察到所有脑结构中PNDO上的氧化剂含量增加。键酶抗氧化剂防污在PNDO上显示出降低的活性。有趣的是，在PND60上，我们观察到大多数抗氧化酶的阳性调节，特别是在前额叶皮质和海马上。在出生时下降并在发育和成人年龄的出生时下降，否定酶促抗氧化防御。在大多数结构的出生时血液过氧化升高，此后减少了效果。在前额叶皮质中，脂质过氧化在出生时未置换并之后减少，而蛋白质氧化在PNDO上增加并在PND60上降低。成人年龄的小脑中蛋白质氧化也降低。我们的结果显示了受控妊娠期CR，以改善抗氧化防御，保护后代脑免受氧化应激，特别是在成年期间，由于发育代谢编程。 （c）2019 Elsevier Inc.保留所有权利。

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  • 来源
    《The Journal of Nutritional Biochemistry》 |2019年第2019期|共11页
  • 作者

    Stone Vinicius; Crestani Mariana Scortegagna; Saccomori Andre Brum; dal Magro Barbara Marino; Maurmann Rafael Moura; August Pauline Maciel; dos Santos Bernardo Gindri; Klein Caroline Peres; Hackenhaar Fernanda Schaefer; Benfato Mara da Silveira; Matte Cristiane;

  • 作者单位

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Programa Posgrad Ciencias Biol Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Dept Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Dept Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Dept Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Dept Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Programa Posgrad Ciencias Biol Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Programa Posgrad Ciencias Biol Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Programa Posgrad Ciencias Biol Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Biociencias Programa Posgrad Biol Mol &

    Celular Ave Bento Gonsclves 9500 Predio 43422 Lab 208B BR-91501970 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Biociencias Programa Posgrad Biol Mol &

    Celular Ave Bento Gonsclves 9500 Predio 43422 Lab 208B BR-91501970 Porto Alegre RS Brazil;

    Univ Fed Rio Grande do Sul Inst Ciencias Basicas Saude Programa Posgrad Ciencias Biol Bioquim Rua Ramiro Barcelos 2600 Anexo Lab 23 BR-90035003 Porto Alegre RS Brazil;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Dietary restriction; Intrauterine environment; Redox status; Metabolic programming; Pregnancy;

    机译：饮食限制;宫内环境;氧化还原状态;代谢编程;怀孕;

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