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首页> 外文期刊>The Journal of Nutritional Biochemistry >Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity
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Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity

机译：膳食纤维补充对肥胖症中微生物群 - 宿主代谢轴的影响

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Low dietary fiber intake is associated with higher rates of microbiota-associated chronic diseases such as obesity. Low-fiber diets alter not only microbial composition but also the availability of metabolic end products derived from fermentation of fiber. Our objective was to examine the effects of dietary fiber supplementation on gut microbiota and associated fecal and serum metabolites in relation to metabolic markers of obesity. We conducted a 12-week, single-center, double-blind, placebo-controlled trial with 53 adults with overweight or obesity. They were randomly assigned to a pea fiber (PF, 15 g/d in wafer form; n=29) or control (CO, isocaloric amount of wafers; n=24) group. Blood and fecal samples were collected at baseline and 12 weeks. Serum metabolomics, gut microbiota and fecal short-chain fatty acids (SCFAs) and bile acids (BAs) were examined. Within-group but not between-group analysis showed a significant effect of treatment on serum metabolites at 12 weeks compared to baseline. Fiber significantly altered fecal SCFAs and BAs with higher acetate and reduced isovalerate, cholate, deoxycholate and total BAs content in the PF group compared to baseline. Microbiota was differentially modulated in the two groups, including an increase in the SCFA producer Lachnospira in the PF group and decrease in the CO group. The change in body weight of participants showed a negative correlation with their change in Lachnospira (r= -0.463, P=.006) abundance. The current study provides insight into the actions of pea fiber and its impact on modulating microbiota-host-metabolic axes in obesity. (C) 2018 Elsevier Inc. All rights reserved.
机译：低膳食纤维摄入量与较高的微生物生物相关慢性疾病如肥胖症相关。低纤维饮食不仅改变微生物组合物，还改变了源自发酵纤维的代谢最终产品的可用性。我们的目的是研究膳食纤维补充对肠道微生物的影响以及相关的粪便和血清代谢物相关的肥胖症的代谢标志。我们进行了12周，单中心，双盲，安慰剂对照试验，53名成年人具有超重或肥胖。将它们随机分配到豌豆纤维（PF，15g / d以晶片形式; n = 29）或对照（CO，异晶晶片量; n = 24）组。在基线和12周内收集血液和粪便样品。检查血清代谢物，肠道微生物瘤和粪便短链脂肪酸（SCFA）和胆汁酸（BAS）。在组内，但在组之间分析介于12周内对血清代谢物进行了显着影响，与基线相比。与基线相比，纤维显着改变粪便SCFA和糖分高，醋酸含量降低，氯酸盐，脱氧胆酸盐和总BAS含量。微生物菌在两组中差异调节，包括PF组中SCFA生产者Lachnospira的增加，并降低了CO组。参与者体重的变化与Lachnospira（r = -0.463，p = .006）丰富的变化表现出负相关性。目前的研究提供了熟悉豌豆纤维的作用及其对调节肥胖症微生物群 - 宿主代谢轴的影响。 （c）2018年Elsevier Inc.保留所有权利。

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