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首页> 外文期刊>The journal of obstetrics and gynaecology research >New antibiotic regimen for preterm premature rupture of membrane reduces the incidence of bronchopulmonary dysplasia
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New antibiotic regimen for preterm premature rupture of membrane reduces the incidence of bronchopulmonary dysplasia

机译：早产的新型抗生素方案过早破裂膜的发生率降低了支气管扩张发育不良的发病率

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Abstract Aim The optimal antibiotic regimen for preterm premature rupture of membrane (pPROM) is still unclear. This study aimed to determine the effects of ampicillin–sulbactam (SBT/ABPC) and azithromycin (AZM) on the incidence of bronchopulmonary dysplasia (BPD). Methods This retrospective study included women with singleton gestations and a diagnosis of pPROM between 22 and 27?weeks of gestation. In patients presenting with a high risk of intra‐amniotic infection between January 2011 and May 2013, piperacillin or cefmetazole + clindamycin (regimen 1 group; n ?=?11) was administered, whereas SBT/ABPC and AZM (regimen 2 group; n ?=?11) were administered in patients presenting a similar risk between June 2013 and May 2016. Results The incidence of moderate or severe infant BPD in the regimen 2 group was significantly lower than that in the regimen 1 group, even when adjusted for gestational age at the time of rupture of membrane, with an odds ratio (95% confidence interval) of 0.02 (1.8?×?10 ?5 –0.33). The incidence of BPD and total days on mechanical ventilation were significantly lower in the regimen 2 group than in the regimen 1 group. No significant differences were seen in other morbidities. Conclusion In patients with pPROM between 22 and 27?weeks of gestation, the administration of SBT/ABPC and AZM may improve the perinatal outcomes.
机译：摘要旨在最佳抗生素治疗膜（PPROM）的早产抗生素方案仍然不清楚。该研究旨在确定氨苄青霉素 - 抑制蛋白（SBT / ABPC）和二十霉素（AZM）对支气管扩张发育不良（BPD）的发病率的影响。方法本次修研究包括患有单身妊娠的妇女，并在22到27周之间诊断PPROM？妊娠周。在2011年1月至2013年5月期间患有高风险的患者，哌啶蛋白酶或哌啶唑醇+ Clindamycin（方案1组; N？=？11），而SBT / ABPC和AZM（方案2组; N. ？=？11）在2013年6月至2016年5月在展出类似风险的患者中施用。结果，中域2组中度或严重婴儿BPD的发病率明显低于妊娠期妊娠在膜破裂时的年龄，具有0.02（1.8Ω·×10？5 -0.33）的差距（95％置信区间）。体育型和机械通气总日的发病率在2组中的制造通气中显着较低，而不是中纲1组。在其他生命中没有看到显着差异。结论在22至27岁之间PPROM患者的妊娠期，SBT / ABPC和AZM的给药可以改善围产期结果。

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