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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis
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The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis

机译：铁蛋白在癌症中的意义：抗氧化，炎症和肿瘤发生

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摘要

The iron storage protein ferritin has been continuously studied for over 70. years and its function as the primary iron storage protein in cells is well established. Although the intracellular functions of ferritin are for the most part well-characterized, the significance of serum (extracellular) ferritin in human biology is poorly understood. Recently, several lines of evidence have demonstrated that ferritin is a multi-functional protein with possible roles in proliferation, angiogenesis, immunosuppression, and iron delivery. In the context of cancer, ferritin is detected at higher levels in the sera of many cancer patients, and the higher levels correlate with aggressive disease and poor clinical outcome. Furthermore, ferritin is highly expressed in tumor-associated macrophages which have been recently recognized as having critical roles in tumor progression and therapy resistance. These characteristics suggest ferritin could be an attractive target for cancer therapy because its down-regulation could disrupt the supportive tumor microenvironment, kill cancer cells, and increase sensitivity to chemotherapy. In this review, we provide an overview of the current knowledge on the function and regulation of ferritin. Moreover, we examine the literature on ferritin's contributions to tumor progression and therapy resistance, in addition to its therapeutic potential.
机译：铁存储蛋白铁蛋白已被持续研究了70多年，其在细胞中作为主要铁存储蛋白的功能已得到充分确立。尽管铁蛋白的细胞内功能大部分已被很好地表征，但人们对血清（细胞外）铁蛋白在人类生物学中的重要性知之甚少。最近，一些证据表明铁蛋白是一种多功能蛋白，可能在增殖，血管生成，免疫抑制和铁传递中起作用。在癌症的情况下，在许多癌症患者的血清中检测到较高水平的铁蛋白，而较高的水平与侵略性疾病和不良的临床预后相关。此外，铁蛋白在与肿瘤相关的巨噬细胞中高表达，最近已经认识到其在肿瘤进展和治疗抗性中具有关键作用。这些特征表明铁蛋白可能成为癌症治疗的诱人靶标，因为其下调可能破坏支持性肿瘤的微环境，杀死癌细胞并增加对化学疗法的敏感性。在本文中，我们概述了有关铁蛋白功能和调节的最新知识。此外，除了其治疗潜力外，我们还研究了有关铁蛋白对肿瘤进展和治疗耐药性的文献。

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