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首页> 外文期刊>Biotechnology Progress >Production of microspheres with surface amino groups from blends ofpoly(lactide-co-glycolide) and poly(epsilon-CBZ-L-lysine) and use forencapsulation
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Production of microspheres with surface amino groups from blends ofpoly(lactide-co-glycolide) and poly(epsilon-CBZ-L-lysine) and use forencapsulation

机译：由聚（丙交酯-乙交酯）和聚（ε-CBZ-L-赖氨酸）的混合物制备具有表面氨基的微球，并将其用于封装

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Microspheres were formed from blends of the biodegradable polymer poly(DL-lacticco-glycolic acid) (PLGA) together with poly(E-CBZ-L-lysine) (PCBZL) by a double-emulsification/solvent evaporation technique. The size of the microspheres formed by this method was dependent both on the total concentration of the polymers and on the ratio of PLGA to PCBZL. The use of the microspheres for encapsulation was demonstrated by the inclusion of a solution of Texas Red fluorescent dye. Lysine E-amino groups on the surface of the microspheres were deprotected by acid hydrolysis or lithium/liquid ammonia reduction. Acid hydrolysis damaged the surface of the microspheres as assessed by scanning electron microscopy, whereas deprotection by lithium/ammonia produced less damage and allowed the retention of encapsulated dye solution. The surface lysine groups made available on the surface of the microspheres could be used to covalently link a variety of biologically active molecules to alter their in vivo properties and allow targeting to specific cell types.
机译：微球是由可生物降解的聚合物聚（DL-乳酸-乙醇酸）（PLGA）与聚（E-CBZ-L-赖氨酸）（PCBZL）的混合物通过双乳化/溶剂蒸发技术形成的。通过这种方法形成的微球的尺寸既取决于聚合物的总浓度，也取决于PLGA与PCBZL的比例。通过包含德克萨斯红荧光染料溶液证明了微球用于封装的用途。微球表面的赖氨酸E-氨基通过酸水解或锂/液氨还原而脱保护。通过扫描电子显微镜评估，酸水解破坏了微球的表面，而锂/氨的脱保护作用则产生了较小的破坏，并保留了封装的染料溶液。在微球表面上可用的表面赖氨酸基团可用于共价连接各种生物活性分子，以改变其体内特性并靶向特定细胞类型。

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