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首页> 外文期刊>AIDS care. >Estimating the impact of alcohol consumption on survival for HIV+ individuals.
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Estimating the impact of alcohol consumption on survival for HIV+ individuals.

机译：估计饮酒对HIV +个体生存的影响。

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Alcohol consumption is associated with decreased antiretroviral adherence, and decreased adherence results in poorer outcomes. However the magnitude of alcohol's impact on survival is unknown. Our objective was to use a calibrated and validated simulation of HIV disease to estimate the impact of alcohol on survival. We incorporated clinical data describing the temporal and dose-response relationships between alcohol consumption and adherence in a large observational cohort (N=2,702). Individuals were categorized as nondrinkers (no alcohol consumption), hazardous drinkers (consume > or =5 standard drinks on drinking days), and nonhazardous drinkers (consume <5 standard drinks on drinking days). Our results showed that nonhazardous alcohol consumption decreased survival by more than 1 year if the frequency of consumption was once per week or greater, and by 3.3 years (from 21.7 years to 18.4 years) with daily consumption. Hazardous alcohol consumption decreased overall survival by more than 3 years if frequency of consumption was once per week or greater, and by 6.4 years (From 16.1 years to 9.7 years) with daily consumption. Our results suggest that alcohol is an underappreciated yet modifiable risk factor for poor survival among individuals with HIV.
机译：饮酒与抗逆转录病毒依从性降低有关，而依从性降低导致预后较差。然而，酒精对生存的影响程度尚不清楚。我们的目标是使用经过校准和验证的HIV疾病模拟来估算酒精对生存的影响。我们纳入了描述大量观察人群（N = 2,702）中饮酒与依从性之间的时间和剂量反应关系的临床数据。个体分为非饮酒者（不饮酒），危险饮酒者（在饮酒日消费>或= 5标准饮料）和非危险饮酒者（在饮酒日消费<5标准饮料）。我们的结果表明，如果每周或一次以上的饮酒频率无害饮酒会使生存期缩短一年以上，而每天饮酒则减少3.3年（从21.7年到18.4年）。如果每周一次或更多次饮酒，有害的酒精消费会使整体生存期降低3年以上，而每天饮酒则降低6.4年（从16.1年到9.7年）。我们的结果表明，酒精是HIV感染者生存不良的一种被低估但可修改的危险因素。

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