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首页> 外文期刊>AIDS care. >Optimal HAART adherence over time and time interval between successive visits: their association and determinants.
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Optimal HAART adherence over time and time interval between successive visits: their association and determinants.

机译：在连续访问之间的时间和时间间隔内，HAART的最佳依从性：它们的关联和决定因素。

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We aimed to investigate the determinants of optimal highly active antiretroviral therapy (HAART) adherence and time interval between successive clinic visits, and the association between these two processes. This was done by reviewing routinely collected patient information in the Centre for the AIDS Programme of Research in South Africa (CAPRISA). Records of 688 patients enrolled in the CAPRISA AIDS treatment (CAT) programme between 2004 and 2006 were analysed. Patients were considered adherent if they had taken at least 95% of their prescribed drugs. The adherence has been measured using the pill counts data. A multivariate generalised mixed random effects approach was used to jointly analyse optimal HAART adherence and time interval between successive visits. The results showed that on the overall, the association between optimal HAART adherence and time interval between successive visits was negative. The results further showed that the interaction between time and treatment site had a significant joint effect on optimal HAART adherence and time interval between successive visits. The interaction revealed that as the number of follow-up visits increased, the interval between successive visits also increased while at the same time high levels of optimal adherence were maintained in the rural treatment site. Moreover, after accounting for the time interval between successive visits, the results showed that optimal HAART adherence was significantly associated with having a cell phone, living with a partner as well as interactions that include time and gender, time and treatment site, age and gender and age and education. The findings provide evidence of a negative association between optimal HAART adherence and the time interval between successive clinic visits on the overall, which therefore indicates that longer time interval between successive clinic visits is undesirable if optimal HAART adherence is to be maintained. This notwithstanding, rural patients were able to maintain HAART adherence for longer time interval between successive clinic visits. Furthermore, the findings indicated that optimal HAART adherence was low for some sub-populations, such as the urban and male populations, thus vigorous ongoing adherence counseling is required.
机译：我们旨在调查确定最佳高效抗逆转录病毒疗法（HAART）的依从性以及连续两次就诊之间的时间间隔，以及这两个过程之间的关联。这是通过在南非艾滋病研究计划中心（CAPRISA）中审查常规收集的患者信息来完成的。分析了2004年至2006年间参加CAPRISA艾滋病治疗（CAT）计划的688位患者的记录。如果患者服用了至少95％的处方药，则被认为是依从性的。使用药丸计数数据测量了依从性。多变量广义混合随机效应方法用于联合分析最佳HAART依从性和两次就诊之间的时间间隔。结果表明，总体而言，最佳HAART依从性与连续访问之间的时间间隔之间的关联为负。结果进一步表明，时间与治疗部位之间的相互作用对最佳HAART依从性和两次就诊之间的时间间隔具有明显的联合影响。交互作用表明，随着随访次数的增加，相继就诊之间的间隔也增加了，与此同时，农村治疗场所仍保持了较高的最佳依从性。此外，在考虑了两次就诊之间的时间间隔后，结果表明，最佳的HAART依从性与手机，与伴侣生活以及互动有关，包括时间和性别，时间和治疗部位，年龄和性别以及年龄和教育程度。这些发现提供了最佳HAART依从性与总体上连续两次就诊之间的时间间隔之间负相关的证据，因此，如果要维持最佳的HAART依从性，则表明不希望连续两次就诊之间存在更长的时间间隔。尽管如此，农村患者仍能够在连续两次就诊之间保持较长时间的HAART依从性。此外，研究结果表明，对于某些亚人群，例如城市和男性人群，最佳的HAART依从性较低，因此需要持续不断的依从性咨询。

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