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首页> 外文期刊>The journal of sexual medicine >Reporting Erectile Function Outcomes After Radiation Therapy for Prostate Cancer: Challenges in Data Interpretation
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Reporting Erectile Function Outcomes After Radiation Therapy for Prostate Cancer: Challenges in Data Interpretation

机译：报告前列腺癌放射治疗后的勃起功能结果：数据解释中的挑战

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Abstract Background Choice of prostate cancer treatment is frequently influenced by the expected chance of treatment-induced side effects such as erectile dysfunction (ED). However, great discrepancy in cited ED rates exists in the contemporary radiation therapy literature. Aim To analyze the reported ED rates and cause of discrepancies and explore the strengths and limitations in the literature on radiation-induced ED. Methods We performed a PubMed literature search and reviewed the literature on ED rates associated with external-beam radiotherapy and brachytherapy from the past 10 years. Eighteen studies were eligible for inclusion and subsequently reviewed. Outcomes Variables required for interpretation of erectile function outcomes, including patient demographics, treatment characteristics, and sexual function outcomes. Results A large variety in the reported incidence of ED was found among studies. In part, these differences resulted from large variations in (i) study populations, (ii) patient characteristics, (iii) treatment characteristics, (iv) prescription of androgen deprivation therapy, (v) means of data acquisition, (vi) definitions of ED, (vii)?temporal considerations, and (viii) erectile aid use. Relevant data required for adequate appraisal of sexual function outcomes were not always reported. Clinical Implications Based on the present findings, we present general recommendations for reporting of erectile function outcomes after radiotherapy for prostate cancer. These should improve future reports. Strengths and Limitations This is the first report that presents general requirements on reporting erectile function outcomes in the setting of radiotherapy for prostate cancer. We did not conduct a formal meta-analysis because we focused on concepts of research design; this might be considered a limitation. Conclusion In this review, we have highlighted the strengths and deficiencies of the current literature on ED after external-beam radiotherapy and brachytherapy for prostate cancer. We have made general recommendations to achieve some degree of standardization among reports and improve clinical interpretability. Wortel RC, Incrocci L, Muhall JP. Reporting Erectile Function Outcomes After Radiation Therapy for Prostate Cancer: Challenges in Data Interpretation. J Sex Med 2017;14:1260–1269.
机译：摘要前列腺癌治疗的背景选择经常受到预期治疗诱导的副作用（如勃起功能障碍）的可能性。然而，当代辐射治疗文献中引用的ED率存在很大的差异。旨在分析据报道的ED率和差异的原因，探讨文献中辐射诱导的ED的优势和局限。方法我们在过去10年中进行了PubMed文献搜索，并审查了与外梁放射治疗和近距离放射治疗相关的ED率的文献。十八项研究有资格包含并随后审查。解释勃起函数结果的结果结果，包括患者人口统计，治疗特征和性功能结果。结果在研究中发现了据报道的ED发病率大。部分地，这些差异是由（i）研究人群的大变化产生的，（ii）患者特征，（iii）治疗特征，（iv）处方，（v）数据习得手段，（vi）定义ED，（VII）？时间考虑因素和（VIII）勃起助剂使用。并不总是报告适当对性职能结果进行充分评估所需的相关数据。根据目前的研究结果，我们介绍了用于报告前列腺癌放射治疗后勃起功能结果的一般性建议。这些应该改善未来的报告。优势和局限性这是第一份报告，呈现关于报告勃起函数结果的一般要求，以在前列腺癌的放射治疗中进行勃起函数结果。我们没有进行正式的荟萃分析，因为我们专注于研究设计的概念;这可能被认为是一个限制。结论在本综述中，我们突出了外梁放射治疗和前列腺癌的近距离放射治疗后ED的目前文献的优势和缺陷。我们已经提出了一般性建议，以在报告中实现一定程度的标准化，并提高临床解释性。 Wortel Rc，Incocci L，Muhall JP。报告前列腺癌放射治疗后的勃起功能结果：数据解释中的挑战。 J SEX MED 2017; 14：1260-1269。

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