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Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice

机译：甲醛抑制了小鼠睾丸中的性行为和类分子化酶的表达

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摘要

Abstract Background Formaldehyde, a ubiquitous environmental pollutant, is used extensively and has been proved to impair male reproduction in mammals. However, no trials have explored whether formaldehyde affects sexual function. Aim To evaluate the effect of long-term formaldehyde exposure on sexual behavior and to investigate the potential mechanism. Methods Forty C57BL/6 male mice were randomly allocated to four equally sized groups. Mice were exposed to formaldehyde at a dose of 0 (control), 0.5, 5.0, or 10.0 mg/m 3 by inhalation for 60 days. Outcomes Sexual behavior, body and reproductive organ weights, testosterone concentration in serum and testicular tissue, expression of steroidogenic enzymes, quality of sperm, and testicular structure were measured. Results Formaldehyde inhibited sexual behavior and decreased reproductive organ weights in mice. Serum testosterone levels and intratesticular testosterone concentrations were decreased in the formaldehyde-treated groups. Expression levels of steroidogenic enzymes, including steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase (3β-HSD), also were decreased in the testes of mice exposed to formaldehyde. Moreover, the structure of seminiferous tubules was destroyed and sperm quality decreased after formaldehyde exposure. In addition, the results indicated that the effects of formaldehyde were dose dependent. Clinical Implications Efforts should be undertaken to decrease impairment of sexual function caused by formaldehyde exposure. Strengths and Limitations The relatively small sample might have affected the outcomes. Further experiments are needed to study the mechanism of action of formaldehyde. Conclusion Exposure to formaldehyde gas inhibited sexual behavior, caused reproductive organ atrophy, and impaired spermatogenesis in male mice, which might have been induced by suppressed expression of steroidogenic enzymes in Leydig cells and decreased testosterone synthesis. Zang Z-J, Fang Y-Q, Ji S-Y, et?al. Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J?Sex Med 2017;14:1297–1306 .
机译：摘要背景甲醛，一种无处不在的环境污染物，被广泛使用，并已被证明在哺乳动物中损害了男性繁殖。但是，没有试验探索甲醛是否会影响性功能。目的评价长期甲醛暴露对性行为的影响，并调查潜在机制。方法将40c57bl / 6雄性小鼠随机分配给四个同等大小的组。通过吸入60天以0（对照），0.5,5.0，或10.0mg / m 3的剂量暴露于甲醛的小鼠。结果性行为，身体和生殖器官重量，血清中睾酮浓度和睾丸组织，测定了类化酶的表达，精子质量和睾丸结构。结果甲醛抑制了老鼠中的性行为和减少生殖器官重量。在甲醛处理基团中降低了血清睾酮水平和细胞内睾酮浓度。在暴露于甲醛的小鼠的睾丸中，在暴露于甲醛的小鼠的睾丸中也减少了类固化性急性调节蛋白，细胞色素急性调节蛋白，细胞色素P450胆固醇侧链切割酶和3β-羟基甾醇脱氢酶（3β-HSD）。此外，甲醛暴露后，破坏了嗜聚小管的结构，并在甲醛暴露后降低。此外，结果表明甲醛的影响依赖于剂量。应努力降低甲醛暴露引起的性功能损害的临床影响。强度和局限性相对较小的样本可能影响了结果。需要进一步的实验来研究甲醛的作用机制。结论暴露于甲醛气体抑制性行为，导致雄性小鼠的生殖器官萎缩，并受损的生物发生，这可能是通过抑制Leydig细胞中的甾体酶的表达和降低的睾酮合成而诱导。 Zang Z-J，Fang Y-Q，Ji S-Y，等等。甲醛抑制了小鼠睾丸中的性行为和类体酶的表达。 J？性医学2017; 14：1297-1306。

著录项

  • 来源
    《The journal of sexual medicine》 |2017年第11期|共10页
  • 作者

    Zhi-Jun Zang; You-Qiang Fang; Su-Yun Ji; Yong Gao; Yuan-Qiang Zhu; Ting-Ting Xia; Mei-Hua Jiang; Ya-Nan Zhang;

  • 作者单位

    Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yat-sen University;

    Department of Urology The Third Affiliated Hospital Sun Yat-sen University;

    Department of Dermatology Guangdong Provincial Dermatology Hospital;

    Reproductive Medicine Centre and Guangdong Provincial Key Laboratory of Reproductive Medicine The;

    Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yat-sen University;

    Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yat-sen University;

    Department of Anatomy Zhongshan School of Medicine Sun Yat-sen University;

    Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yat-sen University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 性卫生;
  • 关键词

    Formaldehyde; Sexual Behavior; Steroidogenic Enzymes; Testosterone; Spermatogenesis; Mice;

    机译：甲醛;性行为;甾体酶;睾酮;精子发生;小鼠;

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