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首页> 外文期刊>Clinical medicine & research. >The prevalence of growth hormone deficiency and celiac disease in short children.
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The prevalence of growth hormone deficiency and celiac disease in short children.

机译：矮小儿童中生长激素缺乏症和腹腔疾病的患病率。

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摘要

OBJECTIVES: To assess the occurrence of growth hormone deficiency (GHD) in patients with celiac disease (CD) referred for short stature. DESIGN: A retrospective, multi-center study. A total of 7066 children with short stature were referred to a number of centers for second-line evaluation over a 5-year period. All patients were screened for CD by antiendomysial antibodies (EMA) and antitissue transglutaminase IgA.Those with positive sera underwent intestinal biopsy. The EMA-negative patients and the EMA-positive ones who did not grow after 1 year of gluten-free diet underwent endocrinological investigation. RESULTS: Among the 7066 short children (age 2-14 years) evaluated, 650 (9.2%) had GHD and 44 (0.63%) had CD. An association of both CD and GHD was found in 16 short children (0.23%); these children did not grow after 1 year of gluten-free diet and therefore GH treatment was started. CONCLUSIONS: GH secretion should be evaluated in celiac patients showing no catch-up growth after an appropriate period on a gluten-free diet in spite of reversion to seronegativity for EMA.
机译：目的：评估身材矮小的乳糜泻（CD）患者中生长激素缺乏症（GHD）的发生。设计：一项回顾性，多中心研究。总共有7066名身材矮小的儿童在5年内被转诊到许多中心进行二线评估。所有患者均通过抗肌内膜抗体（EMA）和抗组织转谷氨酰胺酶IgA筛查CD。血清阳性的患者需进行肠活检。接受了无麸质饮食1年后仍未生长的EMA阴性患者和EMA阳性患者接受了内分泌检查。结果：在7066名2-14岁的矮个子儿童中，有650名（9.2％）患有GHD，有44名（0.63％）患有CD。在16个矮个子的儿童中发现CD和GHD的关联（0.23％）;这些孩子在接受无麸质饮食1年后没有长大，因此开始进行GH治疗。结论：尽管有EMA的血清阴性反应，但仍应在无麸质饮食适当时期后未出现追赶性生长的乳糜泻患者中评估GH分泌。

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