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首页> 外文期刊>AIDS care. >HIV prevention with severely mentally ill men: a randomised controlled trial.
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HIV prevention with severely mentally ill men: a randomised controlled trial.

机译：严重精神病患者的艾滋病毒预防：一项随机对照试验。

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摘要

We conducted a randomised clinical trial to test the efficacy of an enhanced version of an intervention previously shown to reduce HIV sexual risk behaviours among men with severe mental illness. One-hundred-and-forty-nine subjects aged 18-59 years were randomly assigned to the experimental or control conditions. Sexual risk behaviours were assessed every three months for 12-months. The primary analysis compared experimental and control groups with respect to sexual risk behaviours with casual partners as measured by the Vaginal Episodes Equivalent (VEE) score. Additional analyses included comparison of VEE scores of those men sexually active in the three months prior to baseline and the proportion of condom-protected sexual acts with casual partners. There were no significant differences in sexual risk behaviours with casual partners between experimental and control subjects. Additional analyses demonstrated a trend toward sexual risk reduction at six months post-intervention (p=0.06) but not at 12 months. These results may reflect a lack of efficacy or a true reduction in risk that the trial was underpowered to detect at the 0.05-level. If there was a true reduction in risk, it was not maintained after the initial six months.
机译：我们进行了一项随机临床试验，以测试增强干预措施的功效，该干预措施先前显示可减少患有严重精神疾病的男性中的HIV性危险行为。 189名年龄在18-59岁之间的受试者被随机分配到实验或对照条件下。每三个月评估一次性风险行为，持续12个月。初步分析比较了实验组和对照组与随便伴侣的性风险行为，以阴道发作当量（VEE）得分来衡量。其他分析包括比较基线前三个月内从事性活动的男性的VEE得分，以及与休闲伴侣进行安全套保护性行为的比例。实验对象和对照对象之间的休闲伴侣性风险行为没有显着差异。进一步的分析表明，干预后六个月（p = 0.06）但在十二个月时没有降低性风险的趋势。这些结果可能反映出缺乏功效或确实降低了该试验不足以在0.05水平进行检测的风险。如果确实降低了风险，则在最初的六个月后仍无法保持风险。

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