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首页> 外文期刊>AIDS care. >Mediators of antiretroviral adherence: A multisite international study
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Mediators of antiretroviral adherence: A multisite international study

机译：抗逆转录病毒依从性的调解人：一项多点国际研究

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The purpose of this study was to investigate the effects of stressful life events (SLE) on medication adherence (3 days, 30 days) as mediated by sense of coherence (SOC), self-compassion (SCS), and engagement with the healthcare provider (eHCP) and whether this differed by international site. Data were obtained from a cross-sectional sample of 2082 HIV positive adults between September 2009 and January 2011 from sites in Canada, China, Namibia, Puerto Rico, Thailand, and US. Statistical tests to explore the effects of stressful life events on antiretroviral medication adherence included descriptive statistics, multivariate analysis of variance, analysis of variance with Bonferroni post-hoc analysis, and path analysis. An examination by international site of the relationships between SLE, SCS, SOC, and eHCP with adherence (3 days and 30 days) indicated these combined variables were related to adherence whether 3 days or 30 days to different degrees at the various sites. SLE, SCS, SOC, and eHCP were significant predictors of adherence past 3 days for the United States (p = < 0.001), Canada (p = 0.006), and Namibia (p = 0.019). The combined independent variables were significant predictors of adherence past 30 days only in the United States and Canada. Engagement with the provider was a significant correlate for antiretroviral adherence in most, but not all, of these countries. Thus, the importance of eHCP cannot be overstated. Nonetheless, our findings need to be accompanied by the caveat that research on variables of interest, while enriched by a sample obtained from international sites, may not have the same relationships in each country. ? 2013
机译：这项研究的目的是调查应激性生活事件（SLE）对药物依从性（3天，30天）的影响，这种影响是由连贯感（SOC），自我同情（SCS）和与医疗保健提供者的参与介导的（eHCP）以及国际站点是否有所不同。数据来自于2009年9月至2011年1月之间来自加拿大，中国，纳米比亚，波多黎各，泰国和美国的2082名HIV阳性成年人的横断面样本。用于探索紧张生活事件对抗逆转录病毒药物依从性影响的统计测试包括描述性统计，方差的多变量分析，使用Bonferroni事后分析进行的方差分析和路径分析。通过国际站点对SLE，SCS，SOC和eHCP与依从性（3天和30天）之间的关系进行的检查表明，这些组合变量与各个站点上3天或30天不同程度的依从性相关。 SLE，SCS，SOC和eHCP是美国（p = <0.001），加拿大（p = 0.006）和纳米比亚（p = 0.019）过去3天依从性的重要预测指标。仅在美国和加拿大，合并的自变量才是过去30天坚持的重要预测指标。在大多数（但不是全部）这些国家中，与提供者的接触与抗逆转录病毒依从性密切相关。因此，eHCP的重要性不能被夸大。但是，我们的发现需要伴随着警告，即对感兴趣的变量的研究，尽管从国际站点获得的样本中得到了丰富，却在每个国家可能没有相同的关系。 ？ 2013年

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