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Prospective prediction of viral suppression and immune response nine months after ART initiation in Seattle, WA

机译:在华盛顿州西雅图市开展抗病毒治疗后九个月,对病毒抑制和免疫反应的前瞻性预测

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摘要

Knowing at antiretroviral therapy (ART) initiation which patients might be at greatest risk for failure to achieve viral suppression would enable providers to target patients most in need and tailor their care appropriately. This study involved multilevel modeling of data from a randomized controlled trial among outpatients in Seattle, WA, USA. The 224 participants initiating or switching ART at baseline were 24% female, 34% heterosexual, and 47% Caucasian. Of 24 baseline demographic and psychosocial patient-level variables modeled in separate generalized estimating equations, only employment predicted changes in HIV-1 RNA viral load or CD4 lymphocyte count over the course of the 9-month trial. Although the findings require replication, they suggest adherence support strategies should emphasize close monitoring and support for all patients initiating ART. ? 2013
机译:在开始抗逆转录病毒疗法(ART)时,知道哪些患者可能无法实现病毒抑制的风险最大,这将使提供者能够针对最需要的患者并适当地调整其护理。这项研究涉及来自美国华盛顿州西雅图的门诊患者的随机对照试验数据的多级建模。在基线开始或进行抗逆转录病毒治疗的224位参与者中,女性为24%,异性恋为34%,白人为47%。在单独的广义估计方程中建模的24个基线人口统计学和社会心理患者水平变量中,只有就业预测了在9个月试验过程中HIV-1 RNA病毒载量或CD4淋巴细胞计数的变化。尽管研究结果需要重复,但他们建议依从性支持策略应强调对所有发起ART的患者进行密切监测和支持。 ? 2013年

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