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首页> 外文期刊>AIDS care. >Effects of pill burden on discontinuation of the initial HAART regimen in minority female patients prescribed 1 pill/day versus any other pill burden
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Effects of pill burden on discontinuation of the initial HAART regimen in minority female patients prescribed 1 pill/day versus any other pill burden

机译：相对于其他任何药丸剂量，每天开1药丸的少数女性患者，药丸剂量对终止初始HAART方案的影响

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Highly active antiretroviral therapy (HAART) is a mainstay of treatment for patients with Human Immunodeficiency Virus (HIV). Since second line HAART therapies can be costlier and less effective, it is essential to understand the duration of initial HAART therapies. The overall aim of this study was to estimate the effects of daily pill burden on the time to discontinuation of the initial HAART regimen. Patients were initially identified through the clinic's CAREWARE database. A chart review was conducted for data collection, where only adult, female, HIV-positive patients initiating therapy at the study clinic between 1 January 2001 and 31 December 2011 were included. All study subjects were followed up from the initiation of HAART to treatment discontinuation. A Kaplan-Meier curve was generated to describe time to discontinuation by regimens, and a Cox proportional hazards model was developed to assess the impact of different regimen and patient demographic characteristics on the hazard of discontinuation of the initial regimen. A total of 498 charts were initially reviewed. After assessment of these patients for inclusion criteria, a cohort of 115 adult female patients who initiated HAART at the study clinic was included. Patients treated with 1 pill/day regimen had a significantly longer time to discontinuation than regimens of >1 pills/day (mean duration of initial therapy was 1062.56 days vs. 631.70 days, respectively, p = 0.003). Compared to 1 pill/day regimens, >1 pills/day regimens were associated with a higher hazard of discontinuation (hazard ratio (HR) =3.44 with 95% confidence interval (CI) = 1.25, 9.48). A higher viral load and patients without insurance were also found to be significantly associated with increased hazards of discontinuation. Overall, female HIV patients initiating therapy with the 1 pill/day HAART regimen were less likely to discontinue their treatment compared to patients initiating with >1 pills/day HAART regimen.
机译：高效抗逆转录病毒疗法（HAART）是人类免疫缺陷病毒（HIV）患者的主要治疗手段。由于二线HAART疗法可能更昂贵且效果更差，因此了解初始HAART疗法的持续时间至关重要。这项研究的总体目的是估计每日服用药丸量对中断初始HAART方案时间的影响。最初通过诊所的CAREWARE数据库识别患者。进行了图表审查以收集数据，其中仅包括2001年1月1日至2011年12月31日期间在研究诊所开始治疗的成年，女性，HIV阳性患者。从开始进行HAART到治疗终止，均对所有研究对象进行了随访。生成了Kaplan-Meier曲线来描述方案终止治疗的时间，并开发了Cox比例风险模型以评估不同方案和患者人口统计学特征对初始方案终止危害的影响。最初总共审查了498张图表。在评估了这些患者的纳入标准后，纳入了115名在研究诊所发起HAART的成年女性患者。每天接受1丸治疗的患者中止时间比> 1丸/天的患者显着更长（初始治疗的平均持续时间为1062.56天，而631.70天分别为p = 0.003）。与每天1药丸方案相比，> 1丸/天方案与较高的停药风险相关（风险比（HR）= 3.44，95％置信区间（CI）= 1.25，9.48）。较高的病毒载量和无保险的患者也被发现与停药的危险性增加显着相关。总体而言，与每天> 1片HAART方案开始的患者相比，开始每天1丸HAART方案治疗的女性HIV患者中止治疗的可能性较小。

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