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Review of the impact of NNRTI-based HIV treatment regimens on patient-reported disease burden

机译：审查基于NNRTI的HIV治疗方案对患者报告的疾病负担的影响

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While the burden of HIV disease is well documented, the value of non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy regimens in reducing patient burden is not well understood. The purpose of this study was to examine patient-reported health among those receiving NNRTI-based regimens to understand their incremental value in reducing the burden of HIV. We conducted a structured literature review using PubMed to identify NNRTI trials utilizing validated patient-reported outcome (PRO) instruments during 2005-2011. The search strategy included a PubMed search to identify relevant studies based on disease, instrument, PRO, and NNRTI medication terms; and a manual search of bibliographies of identified papers. Data abstracted from each study included study type, treatment regimen(s), and PRO results. Of 11 trials identified, 8 (73%) reported significance of changes in a PRO over time and 10 (91%) reported significance of PRO changes between groups. Several domains were assessed, with significant findings (between or within groups) observed in: physical health/well-being (n = 5), emotional status/well-being (n = 2), symptoms (n = 2), anxiety (n = 2), gastrointestinal upset (n = 2), psychological health (n = 1), functional and global well-being (n = 1), fatigue/energy (n = 1), depression (n = 1), change in body appearance (n = 1), pain (n = 1), headache (n = 1), bad dreamsightmares (n = 1), problems having sex (n = 1), and general health perception (n = 1). In conclusion, NNRTIs have been observed most frequently to improve patient-reported physical health and well-being. Treatments are needed that can also reduce patient burden in areas of emotional well-being, cognitive functioning, and overall symptom profile.
机译：尽管已经充分记录了HIV疾病的负担，但对于减少患者负担的基于非核苷类逆转录酶抑制剂（NNRTI）的治疗方案的价值还知之甚少。这项研究的目的是在接受基于NNRTI的治疗方案的患者中检查患者报告的健康状况，以了解其在减少HIV负担方面的增量价值。我们在2005-2011年期间使用PubMed进行了结构化的文献综述，以使用经过验证的患者报告结果（PRO）仪器确定NNRTI试验。搜索策略包括PubMed搜索，以根据疾病，仪器，PRO和NNRTI用药术语确定相关研究;并手动搜索已鉴定论文的书目。从每项研究中提取的数据包括研究类型，治疗方案和PRO结果。在确定的11个试验中，有8个（73％）报告了PRO随时间变化的显着性，而10个（91％）报告了各组之间PRO的显着性。评估了多个领域，并在以下方面发现了重要的发现（组间或组内）：身体健康/幸福（n = 5），情绪状态/幸福（n = 2），症状（n = 2），焦虑（ n = 2），肠胃不适（n = 2），心理健康（n = 1），功能和整体健康（n = 1），疲劳/精力（n = 1），抑郁（n = 1），变化身体外观（n = 1），疼痛（n = 1），头痛（n = 1），做梦/噩梦（n = 1），性问题（n = 1）和一般健康感知（n = 1 ）。总之，人们最经常观察到NNRTI可以改善患者报告的身体健康状况。需要的治疗方法还可以减轻患者在情绪健康，认知功能和总体症状方面的负担。

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