Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report

Babak Mostafazadeh; Esmaeil Farzaneh; Maryam Paeezi; Farahnaz Nikkhah

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Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report

机译：由于有机磷中毒因阿托品治疗后，有毒的巨型巨胶作为罕见的并发症：案例报告

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The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime. If the poisoning is severe, a high dose of this combination of medicines may be needed, but this may cause serious side effects: paralytic ileus or even megacolon; however, these gastrointestinal events are very rare. Here, we report a case of organophosphate poisoning where atropine therapy was given and led to drug-associated toxic megacolon.

机译：有机磷中毒的案例的主要治疗基础是组合疗法，其包括阿托品作为抗胆碱能药物和Pro硫代肟。如果中毒是严重的，可能需要一种高剂量的药物组合，但这可能导致严重的副作用：麻痹性髂宫甚至兆克隆; 然而，这些胃肠道事件非常罕见。在这里，我们报告了一种有机磷酸盐中毒的情况，其中给予阿托嘌呤疗法并导致药物相关的毒性巨型。

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来源
《The Medico-legal journal》 |2017年第4期|共3页
作者
Babak Mostafazadeh; Esmaeil Farzaneh; Maryam Paeezi; Farahnaz Nikkhah;
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作者单位

Department of Forensic Medicine and Toxicology Shahid Beheshti University of Medical Sciences;

Department of Forensic Medicine and Toxicology Ardabil University of Medical Sciences Ardabil;

Fellowship in Clinical Toxicology Tabriz University of Medical Sciences Tabriz Iran;

Rasoul-e-Akram Hospital Clinical Research Development Center Iran University of Medical Sciences;

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原文格式 PDF
正文语种 eng
中图分类 R89;
关键词
Organophosphate; poisoning; atropine; toxic megacolon;

机译：有机磷;中毒;阿托品;有毒的巨型;

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1. Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report [J] . Babak Mostafazadeh, Esmaeil Farzaneh, Maryam Paeezi, The Medico-legal journal . 2017,第4期

机译：由于有机磷中毒因阿托品治疗后，有毒的巨型巨胶作为罕见的并发症：案例报告
2. Tissue effects of high dose atropine and 2-PAM on healthy rats: Examining their role in complications during treatment of organophosphate poisoning [J] . Betul Gulalp, Derya Gumuldulu, Aysun Uguz, Scientific Research and Essays . 2013,第7期

机译：大剂量阿托品和2-PAM对健康大鼠的组织作用：检查其在有机磷中毒治疗期间并发症中的作用
3. Acute methaemoglobinaemia initially treated as organophosphate poisoning leading to atropine toxicity [J] . Srinivas Kakhandki, Mohammed Yahya, Mudalgi Praveen Indian journal of Anaesthesia . 2012,第4期

机译：急性血红蛋白血症最初被视为有机磷中毒，导致阿托品中毒
4. Interstitial nephritis in a girl with Crohn's disease: a rare complication of mesalazine therapy [C] . D. MUHLBAUER, T. SAUERWALD, S. KOLETZKO Falk Symposium . 2002

机译：克罗恩病的一个女孩中的间质肾炎：茂物嗪治疗的罕见并发症
5. Toxicity of rotenone to common carp and grass carp: Respiratory effects, oral toxicity, and evaluation of a poison bait. [D] . Fajt, James Robert. 1996

机译：鱼藤酮对鲤鱼和草鱼的毒性：呼吸作用，口服毒性和毒饵评价。
6. Ultrastructural changes in rat thyroid tissue after acute organophosphate poisoning and effects of antidotal therapy with atropine and pralidoxime: A single-blind ex vivo study [O] . Deniz Satar, Salim Satar, Ufuk Ozgu Mete, 2008

机译：急性有机磷酸盐中毒后大鼠甲状腺组织的超微结构变化以及阿托品和普利多肟的解毒剂治疗作用：单盲离体研究
7. Paralytic ileus as a complication of atropine therapy following severe organophosphate poisoning [O] . S. C. BEARDS, P. KRAUS, J. LIPMAN 2007

机译：麻痹性肝脏作为阿托嘌呤治疗后严重有机磷酸中毒的并发症

Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report

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