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首页> 外文期刊>AIDS care. >Association between patient engagement in HIV care and antiretroviral therapy medication adherence: cross-sectional evidence from a regional HIV care center in Kenya
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Association between patient engagement in HIV care and antiretroviral therapy medication adherence: cross-sectional evidence from a regional HIV care center in Kenya

机译：患者参与HIV护理与抗逆转录病毒疗法药物依从性之间的关联：来自肯尼亚地区HIV护理中心的横断面证据

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Consistent individual effort in engagement in HIV medical services has been associated with positive health outcomes in people living with HIV (PLHIV). However, whether these benefits are facilitated by improved medication adherence has not been widely studied. This study aimed to investigate the marginal effect of engagement in HIV care on medication adherence at a public health facility in Kenya. Between February and April 2013, 392 patients on HIV care at Nyeri Provincial General Hospital participated in this study. Data were collected using a self-administered health survey questionnaire assessing health and sociodemographic statuses. A manual stepwise general linear model was specified to measure the effect of engagement in HIV and other associated predictors on medication adherence. Engagement in HIV care was significantly associated with log-transformed medication adherence in the sample (100 center dot beta = 9.2%, 95% CI 3.2-15.1) irrespective of gender and other selected predictors. Longer duration on antiretroviral therapy was also a significant predictor of better medication adherence (100 center dot beta = 3.2%, 95% CI 2.3-4.1). Despite inter-gender differences in adherence and engagement determinants, gender's independent effect on medication adherence and engagement in care were not statistically significant. Poor medication adherence was associated with lower patient engagement in HIV care services, suggesting that interventions which remove obstacles to regular observance of scheduled clinic appointments and eventual retention may have a beneficial impact on medication adherence and, accordingly, health outcomes in PLHIV.
机译：个人在艾滋病毒医疗服务中的持续努力与艾滋病毒携带者（PLHIV）的积极健康结局有关。然而，尚未通过改善药物依从性来促进这些益处的研究。这项研究旨在调查肯尼亚一家公共卫生机构从事艾滋病毒护理对药物依从性的边际影响。在2013年2月至4月之间，内里省总医院的392名接受HIV护理的患者参加了这项研究。使用自我管理的健康调查问卷收集数据，以评估健康和社会人口统计学状况。指定了手动逐步通用线性模型，以测量参与HIV和其他相关预测因子对药物依从性的影响。无论性别和其他选定的预测因素如何，参与HIV护理与样本中经对数转换的药物依从性均显着相关（100个中心点beta = 9.2％，95％CI 3.2-15.1）。延长抗逆转录病毒疗法的疗程也是更好的药物依从性的重要预测指标（100个中心点β= 3.2％，95％CI 2.3-4.1）。尽管性别在依从性和参与度决定因素方面存在差异，但性别对药物依从性和护理参与度的独立影响在统计学上并不显着。药物依从性差与患者对HIV护理服务的参与程度降低有关，这表明消除定期遵守预定门诊预约和最终保留障碍的干预措施可能对药物依从性以及因此对PLHIV的健康结局产生有益影响。

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