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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Strength Endurance Training but Not Intensive Strength Training Reduces Senescence-Prone T Cells in Peripheral Blood in Community-Dwelling Elderly Women
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Strength Endurance Training but Not Intensive Strength Training Reduces Senescence-Prone T Cells in Peripheral Blood in Community-Dwelling Elderly Women

机译：强度耐力培训，但不强化强度训练减少了社区住宅老年妇女的外周血中衰老的衰老

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Aging is characterized by a progressive decline in immune function known as immunosenescence. Although the causes of immunosenescence are likely to be multifactorial, an age-associated accumulation of senescent T cells and decreased naive T-cell repertoire are key contributors to the phenomenon. On the other hand, there is a growing consensus that physical exercise may improve immune response in aging. However, the optimum training modality required to obtain beneficial adaptations in older subjects is lacking. Therefore, we aimed to investigate the effects of exercise modality on T-cell phenotypes in older women. A total of 100 women (aged >= 65 years) were randomized to either intensive strength training (80% of one-repetition maximum ), strength endurance training (40% one-repetition maximum), or control (stretching exercise) for 2-3 times per week during 6 weeks. The T-cell percentages and absolute counts were determined using flow cytometry and a hematology analyzer. C-reactive protein was measured using immunonephelometry. We report for the first time that 6 weeks of strength endurance training significantly decreased the basal percentage and absolute counts of senescence-prone T cells, which was positively related to the number of training sessions performed. Conceivably, training protocols with many repetitions-at a sufficiently high external resistance-might assist the reduction of senescence-prone T cells in older women.
机译：老化的特征在于称为免疫功能的逐渐下降。虽然免疫倒期的原因可能是多因素，但衰老T细胞的年龄相关的积累和降低的天真T-Cell reptoire是该现象的关键贡献者。另一方面，存在越来越多的共识，体育锻炼可能会改善老化的免疫反应。然而，缺乏在较旧科目中获得有益适应所需的最佳培训方式。因此，我们旨在探讨运动方式对老年女性T细胞表型的影响。共有100名女性（年龄> = 65岁）被随机随机训练（最大重复的80％），强度耐力训练（最大重复40％），或控制（拉伸运动）2- 6周内每周3次。使用流式细胞术和血液学分析仪测定T细胞百分比和绝对计数。使用免疫乳蛋白测量C-反应蛋白。我们首次报告的是，6周的力量耐力训练显着降低了衰老的衰老 - 易于T细胞的基础百分比和绝对计数，这与所做的培训课程数量有关。可以想象，具有许多重复的训练协议 - 以足够高的外部阻力 - 可能有助于减少老年妇女的衰老易患细胞。

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