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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars.
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Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars.

机译：晚期炎症和健康老龄化的长期评估：心血管健康研究所有恒星。

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Associations of inflammation with age-related pathologies are documented; however, it is not understood how changes in inflammation over time impact healthy aging.We examined associations of long-term change in C-reactive protein (CRP) and interleukin-6 (IL-6) with concurrent onset of physical and cognitive impairment, subsequent cardiovascular disease (CVD), and mortality in 1,051 participants in the Cardiovascular Health Study All Stars Study. Biomarkers were measured in 1996-1997 and 2005-2006.In 2005-2006, median age was 84.9 years, 63% were women and 17% non-white; 21% had at least a doubling in CRP over time and 23% had at least a doubling in IL-6. Adjusting for demographics, CVD risk factors, and 1996-1997 CRP level, each doubling in CRP change over 9 years was associated with higher risk of physical or cognitive impairment (odds ratio 1.29; 95% confidence interval 1.15, 1.45). Results were similar for IL-6 (1.45; 1.20, 1.76). A doubling in IL-6 change over time, but not CRP, was associated with incident CVD events; hazard ratio (95% confidence interval) 1.34 (1.03, 1.75). Doubling in change in each biomarker was individually associated with mortality (CRP: 1.12 [1.03, 1.22]; IL-6 1.39 [1.16, 1.65]). In models containing both change and 2005-2006 level, only level was associated with CVD events and mortality.Although increases in inflammation markers over 9 years were associated with higher concurrent risk of functional impairment and subsequent CVD events and mortality, final levels of each biomarker appeared to be more important in determining risk of subsequent events than change over time.
机译：记录了与年龄相关病理的炎症的关联;然而，没有理解随着时间的推移影响健康老化的炎症变化。我们检查了C-反应蛋白（CRP）和白细胞介素-6（IL-6）的长期变化的关联，并发发作了物理和认知障碍，随后的心血管疾病（CVD），以及1,051名参与者的心血管健康研究中的死亡率所有明星研究。生物标志物于1996 - 1997年和2005 - 2006年测量。2005 - 2006年龄，中位年龄为84.9岁，63％是女性和17％非白;随着时间的推移，21％的CRP至少翻了一番，23％的IL-6至少加倍。调整人口统计数据，CVD风险因素和1996-1997 CRP水平，CRP变化的每倍超过9年，与身体或认知损伤的风险更高（赔率比1.29; 95％置信区间1.15,15,1.45）。 IL-6的结果相似（1.45; 1.20,1.76）。 IL-6随着时间的推移而加倍，但不是CRP，与事件CVD事件相关联;危险比（95％置信区间）1.34（1.03,1.75）。每种生物标志物的变化加倍与死亡率单独相关（CRP：1.12 [1.03,122]; IL-6 1.39 [1.16,1.65]）。在含有变化和2005-2006级的模型中，只有水平与CVD事件和死亡率有关。虽然炎症标志物增加9岁以上的功能性障碍和随后的CVD事件和死亡率，每种生物标记的最终水平相关在确定后续事件的风险方面似乎更重要，而不是随时间的变化。

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