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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Four Genome-Wide Association Studies Identify New Extreme Longevity Variants
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Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

机译：四个基因组关联研究识别新的极端寿命变异

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The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to discover longevity-associated variants (LAV) and characterized those LAVs that differentiate survival to extreme age at death (eSAVs) from those LAVs that become more frequent in centenarians because of mortality selection (eg, survival to younger years). The analyses identified new rare variants in chromosomes 4 and 7 associated with extreme survival and with reduced risk for cardiovascular disease and Alzheimer's disease. The results confirm the importance of studying truly rare survival to discover those combinations of common and rare variants associated with extreme longevity and longer health span.
机译：搜索极端人寿长寿的遗传决定因素受到表型的罕见和调查人员的不特异性定义挑战。为了解决这些问题，我们建立了四个关于极端寿命的四项研究的财团，贡献了2,070人，他们幸存到1900美元的最古老的生存百分之一。我们进行了各种分析以发现寿命相关的变体（LAV），并将这些熔体分解为死亡（勘探酵母）的生存，因为死亡率选择（例如，生存为年轻的年龄）。该分析鉴定了与极端存活相关的染色体4和7中的新稀有变体，并降低了心血管疾病和阿尔茨海默病的风险。结果证实了学习真正罕见的生存的重要性，以了解与极端寿命和更长的健康跨度相关的常见和罕见变种的组合。

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