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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women
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Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women

机译：白藜芦醇增强了老年男性和女性骨骼肌的运动诱导的细胞和功能调整

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Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (RSV) (500 mg/d) to test the hypothesis that RSV treatment combined with exercise would increase mitochondrial density, muscle fatigue resistance, and cardiovascular function more than exercise alone. Contrary to our hypothesis, aerobic and resistance exercise coupled with RSV treatment did not reduce cardiovascular risk further than exercise alone. However, exercise added to RSV treatment improved the indices of mitochondrial density, and muscle fatigue resistance more than placebo and exercise treatments. In addition, subjects that were treated with RSV had an increase in knee extensor muscle peak torque (8%), average peak torque (14%), and power (14%) after training, whereas exercise did not increase these parameters in the placebo-treated older subjects. Furthermore, exercise combined with RSV significantly improved mean fiber area and total myonuclei by 45.3% and 20%, respectively, in muscle fibers from the vastus lateralis of older subjects. Together, these data indicate a novel anabolic role of RSV in exercise-induced adaptations of older persons and this suggests that RSV combined with exercise might provide a better approach for reversing sarcopenia than exercise alone.
机译：年龄较大的男人（n = 12）和女性（n = 18）65-80岁完成12周的运动，并采用安慰剂或白藜芦醇（RSV）（500 mg / d）来测试RSV治疗结合的假设锻炼将增加线粒体密度，肌肉疲劳性和心血管功能超过单独的运动。与我们的假设相反，与RSV治疗相结合的有氧和抗性运动并未仅降低携带的心血管风险。然而，添加到RSV治疗中的运动改善了线粒体密度的指标，并且肌肉疲劳性抵抗超过安慰剂和运动处理。此外，用RSV处理的受试者在训练后，膝关节伸肌峰值扭矩（8％），平均峰值扭矩（14％）和功率（14％）的增加，而运动并未在安慰剂中增加这些参数 - 改性较老的科目。此外，在来自较老科的大量侧面的肌肉纤维中，锻炼与RSV显着改善的平均纤维面积和总核核相结合。这些数据在一起表明RSV在运动诱导的老年人适应方面的一种新颖的合成代谢作用，这表明RSV与运动相结合，可以提供比单独锻炼的更好方法。

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