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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice
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Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice

机译：“瓦伦西亚评分”量化量为小鼠寿命的潜在预测因子

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The development of frailty scores suitable for mice and which resemble those used in the clinical scenario is of great importance to understand human frailty. The aim of the study was to determine an individual frailty score for each mouse at different ages and analyze the association between the frailty score and its lifespan. For this purpose, the “Valencia Score” for frailty was used. Thus, a longitudinal study in mice was performed analyzing weight loss, running time and speed, grip strength and motor coordination at the late-adult, mature and old ages (40, 56 and 80 weeks old, respectively). These parameters are equivalent to unintentional weight loss, poor endurance, slowness, weakness, and low activity level, respectively, in humans. A cut-off point was used to identify frail mice for each criterion. All the measurements were also performed on chronologically adult prematurely aging mice. The results show that by using the “Valencia Score” for frailty a prematurely aged phenotype can be identified even during the adulthood of animals. This opens up the possibility of carrying out preventive long-term interventions. Moreover, the individual frailty score of a given mouse at the late-adult, mature and old ages is shown to be a relevant predictor of its lifespan.
机译：适合小鼠的体外评分的发展，并且类似于临床情景中使用的比例的发展是非常重要的，可以理解人类脆弱。该研究的目的是在不同年龄的每只小鼠确定每个鼠标的个体脆弱分数，并分析脆差分数与其寿命之间的关联。为此，使用了脆弱的“瓦伦西亚评分”。因此，在晚期成人，成熟和旧年龄（分别为40,56和80周）的体重减轻，运行时间和速度，握力和电机协调进行分析小鼠的纵向研究。这些参数相当于人类中的无意减肥，耐久性，缓慢，弱势和低活性水平。截止点用于识别每个标准的脆小鼠。所有测量也在年代成人过早老化小鼠上进行。结果表明，即使在动物的成年期间，通过使用用于脆弱的脆弱的表型的“瓦伦西亚评分”即使在动物的成年期间也可以鉴定。这开辟了履行预防性长期干预的可能性。此外，在晚期成人，成熟和旧年龄的特定鼠标的个体体外得分被认为是其寿命的相关预测因素。

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