APOE Alleles and Extreme Human Longevity

Sebastiani Paola; Gurinovich Anastasia; Nygaard Marianne; Sasaki Takashi; Sweigart Benjamin; Bae Harold; Andersen Stacy L.; Villa Francesco; Atzmon Gil; Christensen Kaare; Arai Yasumichi; Barzilai Nir; Puca Annibale; Christiansen Lene; Hirose Nobuyoshi; Perls Thomas T.

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APOE Alleles and Extreme Human Longevity

机译：Apoe等位基因和极端人类长寿

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We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.

机译：我们组建了来自七个研究寿命和健康老龄观念的28,297名参与者的集合，包括新英格兰百年人，长寿，长寿基因人口，南部意大利百年人，日本人，丹麦人，丹麦人寿，以及卫生和退休研究，以研究协会 Apoe等位基因，但只有在达到人口的年龄不到1％的年龄的死亡风险的风险。

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来源
《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2019年第1期|共8页
作者
Sebastiani Paola; Gurinovich Anastasia; Nygaard Marianne; Sasaki Takashi; Sweigart Benjamin; Bae Harold; Andersen Stacy L.; Villa Francesco; Atzmon Gil; Christensen Kaare; Arai Yasumichi; Barzilai Nir; Puca Annibale; Christiansen Lene; Hirose Nobuyoshi; Perls Thomas T.;
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作者单位

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Univ Southern Denmark Danish Aging Res Ctr Odense Denmark;

Keio Univ Ctr Supercentenarian Res Tokyo Japan;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Oregon State Univ Coll Publ Hlth &

Human Sci Corvallis OR 97331 USA;

Boston Univ Sch Med Dept Med Geriatr Sect Boston MA 02118 USA;

IRCCS MultiMed Cardiovasc Res Unit Milan Italy;

Univ Haifa Fac Nat Sci Haifa Israel;

Univ Southern Denmark Danish Aging Res Ctr Odense Denmark;

Keio Univ Ctr Supercentenarian Res Tokyo Japan;

Albert Einstein Coll Med Dept Med &

Genet Bronx NY 10467 USA;

IRCCS MultiMed Cardiovasc Res Unit Milan Italy;

Univ Southern Denmark Danish Aging Res Ctr Odense Denmark;

Keio Univ Ctr Supercentenarian Res Tokyo Japan;

Boston Univ Sch Med Dept Med Geriatr Sect Boston MA 02118 USA;

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原文格式 PDF
正文语种 eng
中图分类老年病学;
关键词
APOE; Extreme human longevity; Genetic association; Survival distribution;

机译：Apoe;极端人类长寿;遗传结社;生存分布;

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专利

1. APOE Alleles and Extreme Human Longevity [J] . Sebastiani Paola, Gurinovich Anastasia, Nygaard Marianne, The journals of gerontology.Series A. Biological sciences and medical sciences . 2019,第1期

机译：Apoe等位基因和极端人类长寿
2. Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants [J] . Ukraintseva Svetlana, Yashin Anatoliy, Arbeev Konstantin, Biogerontology . 2016,第1期

机译：遗传风险因素在人类寿命中的令人困惑的作用：“风险等位基因”作为延长寿命的变体
3. Inverse Association Between Height-Increasing Alleles and Extreme Longevity in Japanese Women [J] . KumpeiTanisawa, NobuyoshiHirose, YasumichiArai, The journals of gerontology.Series A. Biological sciences and medical sciences . 2018,第5期

机译：日本女性高度增加的等位基因和极端寿命之间的逆关联
4. Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity Results of Studies Performed in a Sicilian Population [C] . GIUSEPPINA CANDORE, CARMELA RITA BALISTRERI, MARIA PAOLA GRIMALDI, International Association of Biomedical Gerontology International . 2006

机译：促炎等位基因在急性心肌梗死中的作用相反，在西西里人群中进行的研究的寿命结果
5. Engineering Human Induced Pluripotent Stem Cells (hiPSCs) to Investigate the Contribution of the APOE Risk Allele to the Onset and Progression of Alzheimer’s Disease [D] . Brookhouser, Nick. 2020

机译：工程人诱导多能干细胞（HIPSC）以研究Apoe风险等位基因对阿尔茨海默病发放和进展的贡献
6. APOE Alleles and Extreme Human Longevity [O] . Paola Sebastiani, Anastasia Gurinovich, Marianne Nygaard, -1

机译：APOE等位基因与人类的长寿
7. Alleles of the Human Mu Opioid Receptor, Diagnostic Methods using said Alleles, and Methods of Treatment Based Thereon. [R] . Kreek, M. J., LaForge, K. S. 2006

机译：人类mu阿片受体的等位基因，使用所述等位基因的诊断方法，以及基于其的治疗方法。

APOE Alleles and Extreme Human Longevity

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