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首页> 外文期刊>AIDS care. >Adherence to antiretroviral therapy in children: a comparative evaluation of caregiver reports and physician judgement.
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Adherence to antiretroviral therapy in children: a comparative evaluation of caregiver reports and physician judgement.

机译：坚持儿童抗逆转录病毒疗法：对保姆报告和医师判断的比较评估。

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摘要

Adherence to antiretroviral (ART) therapy, as reported by children caregivers, was investigated and compared with physicians' estimates of adherence. Two parallel structured questionnaires were administered to caregivers of 129 HIV-infected children and to their physicians in seven different Italian reference centers. Doses omitted in the last four days were recorded. Perfect adherence (>95% of prescribed doses taken in the last four days before interview) was reported by caregivers of 103 (79%) children. Five children (5%) omitted one dose of any ART drug in four days and were considered adherent. Low (<95 but >80% of doses) and poor (<80% of doses) adherence were reported by 15 (12%) and six (5%) caregivers, respectively. Forty-eight children (37%) were judged to be non-adherent by their physicians, including 35 children who were receiving all the prescribed doses according to caregivers. The physicians identified eight out of the 21 non-adherent children as adherent. Non-adherence estimates by physicians closely correlated with poor clinical conditions. These data indicate that adherence is a major problem but there is a clear discrepancy between caregiver reports and physician judgement. The results underline the need of close surveillance of adherence in HIV-positive children in order to evaluate the effectiveness of ART therapy.
机译：儿童照护者报告了对坚持抗逆转录病毒（ART）治疗的依从性，并与医生对依从性的估计进行了比较。在意大利七个不同的参考中心，对129名感染艾滋病毒的儿童的看护者及其医生进行了两份平行的结构化问卷调查。记录最近四天遗漏的剂量。 103名儿童（79％）的照护者报告称完全依从（在访谈前的最后四天中服用的处方剂量为95％以上）。五名儿童（5％）在四天内未服用一剂任何抗逆转录病毒药物，被认为是依从性的。 15（12％）和6（5％）的照护者分别报告了依从性低（<95％，但> 80％的剂量）和不良（<80％的剂量）。他们的医师将48名儿童（37％）判定为不依从，其中包括35名根据照护者规定接受所有处方剂量的儿童。医生确定了21名非依从儿童中的8名是依从儿童。医生的不依从估计与不良的临床状况密切相关。这些数据表明，依从性是一个主要问题，但看护人报告与医生判断之间存在明显差异。结果强调需要密切监测HIV阳性儿童的依从性，以评估ART治疗的有效性。

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