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首页> 外文期刊>AIDS care. >A comparison of risk factors for atypical squamous cells and squamous intraepithelial lesions in a sample of US- and African-born HIV-positive women.
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A comparison of risk factors for atypical squamous cells and squamous intraepithelial lesions in a sample of US- and African-born HIV-positive women.

机译：在美国和非洲出生的HIV阳性妇女的样本中，比较了非典型鳞状细胞和鳞状上皮内病变的危险因素。

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摘要

Previous research conducted in the USA and Africa has identified human immunodeficiency virus (HIV) infection as a risk factor for women developing squamous intraepithelial lesion (SIL) diagnosis. This study was conducted to compare the odds of a diagnosis of atypical squamous cells (ASCUS) or SIL in a sample of mostly African-born and US-born women (n=275). A greater proportion of US-born women had an ASCUS (68.9%) or SIL (81.3%) diagnosis than African-born women (29.5% ASCUS, 15.6% SIL). After adjusting for age, smoking status, absolute CD4, and a prescription for HIV-antiviral medications, the US-born women had a greater odds of a SIL diagnosis than the African-born women (OR=0.22, 95% CI: 0.06-0.79); no significant differences in ASCUS remained after adjustment. In this sample, proportionately more African-American (55.3%) and white American (51.1%) women smoke tobacco than African-born women (1.9%), explaining, perhaps, some of the difference. We found that an absolute CD4 less than 200, when compared to an absolute CD4 above 500, was highly predictive of a SIL diagnosis (OR=6.31, 95% CI: 2.10-18.93, p-trend <0.01). A prescription for HIV-antiviral medications was not a significant predictor of an ASCUS or SIL diagnosis.
机译：先前在美国和非洲进行的研究已经确定，人类免疫缺陷病毒（HIV）感染是女性发展为鳞状上皮内病变（SIL）诊断的危险因素。这项研究的目的是在大多数非洲裔和美国裔妇女（n = 275）的样本中比较诊断出非典型鳞状细胞（ASCUS）或SIL的几率。在美国出生的女性中，诊断为ASCUS（68.9％）或SIL（81.3％）的比例要高于非洲出生的女性（29.5％ASCUS，15.6％SIL）。在调整了年龄，吸烟状况，绝对CD4以及HIV抗病毒药物的处方后，美国出生的女性比非洲出生的女性更有可能被诊断为SIL（OR = 0.22，95％CI：0.06- 0.79）;调整后，ASCUS没有显着差异。在此样本中，吸烟的非裔美国人（55.3％）和白人美国人（51.1％）比例要比非洲出生的妇女（1.9％）高得多，这或许可以解释其中的一些差异。我们发现，与大于500的CD4相比，小于200的CD4可以高度预测SIL的诊断（OR = 6.31，95％CI：2.10-18.93，p趋势<0.01）。 HIV抗病毒药物的处方并不是ASCUS或SIL诊断的重要预测指标。

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