...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction
【24h】

Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction

机译：肾功能和锻炼训练在射血分数减少的患者

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Patients with chronic kidney disease (CKD) and/or end-stage renal disease are less active and experience significant functional limitations. The impact of a structured aerobic exercise intervention on outcomes in ambulatory heart failure (HF) patients with comorbid CKD is unknown.HF-ACTIONenrolled 2,331 outpatients with HF and a reduced ejection fraction (i.e., ≤35%) from April 2003 to February 2007 and randomized them to aerobic exercise training versus usual care. Patients were grouped according to the presence of CKD, defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2. A total of 2,091 patients (90%) had serum creatinine measured and were included in the final analytical cohort. The prevalence of CKD was 41% at baseline. In patients with and without CKD, respectively, the incidence of all-cause death and hospitalization was 75% and 63% over a median follow-up of 30 months. After adjusting for potential confounders, CKD was associated with increased risk of the composite of all-cause mortality and hospitalization (hazard ratio 1.18, 95% confidence interval 1.04 to 1.33; p value ≤0.01). With the exception of a marginally greater improvement in exercise duration in response to aerobic exercise training (estimate ± standard error: 0.9 ± 0.2 minutes vs 1.4 ± 0.1 minutes; p value?=?0.01), there was no interaction between treatment arm and CKD on functional status, health-related quality of life, or clinical outcomes (p value ≥0.05 for all interactions). In conclusion, the prevalence of CKD was high in ambulatory reduced ejection fraction patients and was associated with a poorer overall prognosis but not a differential response to aerobic exercise training.
机译：患有慢性肾病（CKD）和/或末期肾病的患者不太活跃，经历显着的功能限制。结构化的有氧运动干预对动态心力衰竭（HF）患者的影响的影响是未知的.HF-actionEnrolled的2,331名患有HF的门诊病，从2003年4月到2007年2月和2007年2月的降低的射血分数（即≤35％）和随机地将它们与常规护理相比有氧运动训练。患者根据CKD的存在进行分组，定义为估计的肾小球过滤速率<60ml / min / 1.73m 2。共测量了2,091名患者（90％），血清肌酐测量，并包含在最终分析队列中。基线CKD的患病率为41％。在没有CKD的患者中，全导致死亡和住院的发生率为75％，63％在30个月的中间随访中。在调整潜在混血剂后，CKD与全导致死亡率和住院复合的综合风险增加（危险比1.18,95％置信区间1.04至1.33; P值≤0.01）。除了对运动持续时间的锻炼持续时间有略微提高（估计±标准误差：0.9±0.2分钟，比1.4±0.1分钟; P值？= 0.01），治疗臂和CKD之间没有相互作用关于功能状况，与健康相关的生命质量，或临床结果（所有相互作用的P值≥0.05）。总之，CKD的患病率在动态降低的喷射分数患者中高，与整体预后较差，而不是对有氧运动训练的差异反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号