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首页> 外文期刊>AIDS care. >Prevalence and correlates of willingness to participate in a rectal microbicide trial among men who have sex with men in Bangkok
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Prevalence and correlates of willingness to participate in a rectal microbicide trial among men who have sex with men in Bangkok

机译：在曼谷与男性发生性关系的男性中参加直肠杀菌剂试验的普遍性和相关性

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摘要

Rectal microbicides (RMs) hold promise as a HIV prevention method to reduce transmission among men who have sex with men (MSM). To assess RM trial feasibility in Bangkok, we measured prevalence and correlates of willingness to participate among Thai MSM observational cohort participants. Between April 2006 and December 2010, 1744 MSM enrolled in the Bangkok MSM Cohort Study; at 12 months, RM trial participation willingness was measured. We evaluated correlates of RM trial participation willingness using logistic regression analysis. Participants completing the 12-month visit (81.4%, n = 1419) had a mean age of 27.3 years (SD = 6.1), and 65.5% and 86.1% reported having a steady partner or anal intercourse (AI) in the past four months, respectively. Most (79.1%, n = 1123) participants reported willingness to participate in an RM trial, which, in multivariable analysis, was independently associated with insertive only (adjusted odds ratio [AOR] = 3.25, 95% CI: 1.82-5.81) or receptive/versatile role AI (AOR = 3.07, 95% CI: 1.88-5.01), and being paid for sex (AOR = 12.15, 95% CI: 1.67-88.21) in the past four months, and believing that people with AIDS look sick (AOR = 1.92, 95% CI: 1.23-2.98). Of hypothetical RM trial features to increase enrollment likelihood, the most (91.1%) compelling was that the study be approved by the Thai ethics committee, followed by the study site offering evening hours (88.9%). Reasons not to participate were not wanting a rectal examination (29.5%) or fluid collected from the penis or anus (24.6%) and not wanting the placebo (23.0%). RM trial participation willingness was high, particularly for those with greater HIV acquisition risk, within this Thai MSM cohort, suggesting feasibility of an RM trial. Addressing potential barriers to trial entry may be useful in educational materials to optimize recruitment.
机译：直肠杀菌剂（RM）有望作为一种HIV预防方法来减少与男性发生性行为（MSM）的男性之间的传播。为了评估在曼谷进行RM试验的可行性，我们测量了泰国MSM观察队列参与者中的患病率和参与意愿的相关性。在2006年4月至2010年12月之间，有1744名MSM参加了曼谷MSM队列研究;在12个月时，对RM试验的参与意愿进行了测量。我们使用逻辑回归分析评估了RM试验参与意愿的相关性。完成12个月访问的参与者（81.4％，n = 1419）的平均年龄为27.3岁（SD = 6.1），并且在过去四个月中，有稳定伴侣或肛门性交（AI）的参与者分别为65.5％和86.1％ ， 分别。大多数参与者（79.1％，n = 1123）表示愿意参加RM试验，在多变量分析中，RM试验仅与插入性干预独立相关（调整后的优势比[AOR] = 3.25，95％CI：1.82-5.81）或具有接受/多功能作用的AI（AOR = 3.07，95％CI：1.88-5.01），并且在过去四个月内因性行为而获得报酬（AOR = 12.15，95％CI：1.67-88.21），并相信艾滋病患者的外貌生病的（AOR = 1.92，95％CI：1.23-2.98）。假设的RM试验可增加入组可能性，其中最令人信服的（91.1％）是该研究由泰国伦理委员会批准，其次是晚上提供研究时间（88.9％）。不参加的原因是不想进行直肠检查（29.5％）或从阴茎或肛门收集的液体（24.6％），而不想要安慰剂（23.0％）。在该泰国MSM队列中，RM试验的参与意愿很高，尤其是对于那些具有更大HIV感染风险的人群，这表明RM试验的可行性。解决潜在的试行障碍可能对优化招聘的教育材料有用。

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