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Biomarkers and prognosis in malignant lymphomas

机译:恶性淋巴瘤的生物标志物和预后

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Approximately 100 hematologists and pathologists from Europe, the United States, and Canada participated in the workshop Biomarkers and Prognosis in Malignant Lymphomas, held in Mandelieu, France, April 11-13, 2008, under the leadership of Anton Hagenbeek, Randy Gascoyne, and Gilles Salles. International experts in the field (discussed herein) shared their experiences in exploring the role of a variety of biologic markers related to different types of non-Hodgkin lymphomas (follicular, diffuse large B-cell, mantle cell, and Burkitt lymphomas) as well as Hodgkin lymphoma. The final goal of this clinical research is to develop new biologic prognostic indices for these major subtypes of lymphoma. In recent years, various prognostic indices, mainly based on clinical characteristics of the patient at diagnosis, have served to determine the prognostic profile and to develop prognostic factor-based treatment strategies. However, it is now time to reconsider this based on the wealth of new biologic information directly related to lymphoma cells and the surrounding cells. In this workshop, organized by the European School of Hematology and the European Hematology Association, the latest developments on molecular pathogenesis, new biomarkers, and their relation to prognosis were extensively discussed. Herein, the major conclusions presented in the different sessions are summarized.
机译:来自欧洲,美国和加拿大的约100名血液学家和病理学家参加了在Anton Hagenbeek,Randy Gascoyne和Gilles的领导下于2008年4月11日至13日在法国曼德琉举行的恶性淋巴瘤生物标志物和预后研讨会。萨尔斯。该领域的国际专家(本文讨论)分享了他们在探索与不同类型的非霍奇金淋巴瘤(滤泡性,弥漫性大B细胞,套细胞和Burkitt淋巴瘤)有关的各种生物标志物的作用方面的经验。霍奇金淋巴瘤。这项临床研究的最终目标是为这些主要的淋巴瘤亚型开发新的生物学预后指标。近年来,主要基于诊断时患者的临床特征的各种预后指标已用于确定预后情况并制定基于预后因素的治疗策略。但是,现在是时候根据大量与淋巴瘤细胞和周围细胞直接相关的新生物信息重新考虑这一点。在由欧洲血液学学院和欧洲血液学协会组织的研讨会上,广泛讨论了分子发病机制,新生物标志物及其与预后的关系的最新进展。在此,总结了不同会议中提出的主要结论。

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