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首页> 外文期刊>AIDS care. >Factors affecting attrition in a longitudinal study of patients with AIDS.
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Factors affecting attrition in a longitudinal study of patients with AIDS.

机译：在艾滋病患者的纵向研究中影响损耗的因素。

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Anecdotal data have suggested that retention of HIV-infected patients with immune recovery in longitudinal studies may be difficult as they resume normal activities. This study evaluated risk factors for attrition among patients with AIDS in a cohort study in the era of highly active antiretroviral therapy. Patients with AIDS enrolled in the Longitudinal Study of Ocular Complications of AIDS were evaluated every three months with demographic, clinical and laboratory data collected. Lost to follow-up was defined as any patient who missed all study visits and could not be contacted for 12 consecutive months, who had not died and who did not re-enter the study at a later date. Of the 1,052 patients studied, 77 (7.3%) were lost to follow-up (rate = 0.03/person year). In the multivariate analysis, factors associated with attrition were CD4+ T-cell count category (hazard ratio (HR) = 2.03; 95%CI: 1.01, 4.24; P = 0.05 for CD4+ count < or = 50 cells/microL and HR = 1.96; 95%CI: 1.12, 3.40; P = 0.02 for CD4+ count 51-200 cells/microL) and detectable HIV viral load (HR 1.29; 95%CI: 1.07, 1.53; P < 0.001 for HIV viral load >400 copies/mL). These data suggest that patients with compromised immunologic status are at an increased risk for being lost to follow-up.
机译：轶事数据表明，在纵向研究中保留HIV感染者并进行免疫恢复的患者可能很难恢复正常活动。这项研究在一项高效抗逆转录病毒治疗时代的队列研究中评估了AIDS患者流失的危险因素。每三个月对参与艾滋病眼部并发症纵向研究的艾滋病患者进行人口，临床和实验室数据评估。失去随访的定义为：错过所有研究访问且连续12个月无法联系，未死亡且以后未重新进入研究的任何患者。在研究的1052名患者中，有77名（7.3％）失访（比率= 0.03 /人年）。在多变量分析中，与损耗相关的因素是CD4 + T细胞计数类别（危险比（HR）= 2.03; 95％CI：1.01、4.24; CD4 +计数<或= 50细胞/ microL和HR = 1.96的P = 0.05） ; 95％CI：1.12，3.40; CD4 +计数51-200细胞/微升P = 0.02）和可检测到的HIV病毒载量（HR 1.29; 95％CI：1.07，1.53; HIV病毒载量> 400拷贝/ P <0.001毫升）。这些数据表明免疫状态受损的患者失去随访的风险增加。

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