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首页> 外文期刊>AIDS care. >Problems taking pills: understanding HIV medication adherence from a new perspective.
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Problems taking pills: understanding HIV medication adherence from a new perspective.

机译：服用药片的问题：从新的角度了解艾滋病毒药物的依从性。

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HIV medication adherence remains a challenge for people taking antiretroviral therapy. In the last decade research in this area has proliferated, yet there is a need for novel research approaches that provide information on the development of successful medication adherence interventions. This study examined several key potential correlates of reasons for missed medication in a diverse sample of people living with HIV/AIDS (PLWHA) from nine cities in the US using an ordinal regression model. Examining the reasons for missed medication in relationship with regimen type, symptom experience, AIDS diagnosis, other health conditions, and social support offers a new approach. Problems taking pills (a factor of five reasons) was significantly associated (p=0.003) with use of a protease inhibitor (PI) regimen. A person taking a PI regimen has a 70% increase of having more problems taking pills versus a non-PI regimen. Symptom experience (odds ratio [OR]: 3.8; 95% confidence interval [CI]: 2.7, 5.2) and other health conditions (OR: 0.7; 95% CI: 0.45, 0.98) were found to be independently associated with problems taking pills. This new perspective may provide a framework for further conceptualizing new analyses that are related to enhancing adherence intervention research and development.
机译：坚持抗艾滋病毒治疗仍然是人们接受抗逆转录病毒疗法的挑战。在过去的十年中，该领域的研究激增，但仍需要新颖的研究方法，以提供有关成功的药物依从性干预措施发展的信息。这项研究使用序数回归模型研究了美国九个城市的艾滋病毒/艾滋病感染者（PLWHA）样本中药物遗漏原因的几个关键潜在相关性。通过与治疗方案类型，症状经历，艾滋病诊断，其他健康状况和社会支持的关系来检查药物遗漏的原因，提供了一种新方法。服用药片的问题（有五个原因）与蛋白酶抑制剂（PI）方案的使用显着相关（p = 0.003）。与非PI方案相比，服用PI方案的人服用药有更多问题的可能性增加了70％。发现症状经历（几率[OR]：3.8; 95％置信区间[CI]：2.7、5.2）和其他健康状况（OR：0.7; 95％CI：0.45、0.98）与服用药片的问题独立相关。这个新的观点可以为进一步概念化与加强依从性干预研究和开发有关的新分析提供一个框架。

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