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首页> 外文期刊>The journal of physiological sciences: JPS >Natural silibinin modulates amyloid precursor protein processing and amyloid-beta protein clearance in APP/PS1 mice
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Natural silibinin modulates amyloid precursor protein processing and amyloid-beta protein clearance in APP/PS1 mice

机译：天然硅藻蛋白在APP / PS1小鼠中调节淀粉样蛋白前体蛋白质处理和淀粉样蛋白-β蛋白质清除

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摘要

Silibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (A beta) aggregation in Alzheimer's disease (AD) models. However, the underlying mechanism by which silibinin improves cognition remains poorly understood. In this study, we investigated the effect of silibinin on beta-secretase levels, A beta enzymatic degradation, and oxidative stress in the brains of APP/PS1 mice with cognitive impairments. Oral administration of silibinin for 2 months significantly attenuated the cognitive deficits of APP/PS1 mice in the Y-maze test, novel object recognition test, and Morris water maze test. Biochemical analyses revealed that silibinin decreased A beta deposition and the levels of soluble A beta 1-40/1-42 in the hippocampus by downregulating APP and BACE1 and upregulating NEP in APP/PS1 mice. In addition, silibinin decreased the MDA content and increased the activities of the antioxidant enzymes CAT, SOD, and NO. Based on our findings, silibinin is a potentially promising agent for preventing AD-associated A beta pathology.
机译：已显示硅丙蛋白可衰减认知功能障碍并抑制阿尔茨海默病（AD）模型中的淀粉样蛋白β（Aβ）聚集。然而，硅蛋白改善认知的潜在机制仍然明显差不多。在这项研究中，我们研究了硅蛋白对β-分泌酶水平，β酶降解和具有认知障碍的脑的β-酶降解和氧化应激的影响。硅蛋白的口服给药2个月显着减弱了Y型迷宫试验，新型物体识别试验和莫里斯水迷宫试验中的应用程序/ PS1小鼠的认知缺陷。生物化学分析显示，硅蛋白通过下调APP和BACE1和UpReguling Nep在AP / PS1小鼠中降低了海马中的β沉积和溶于β1-40/ 1-42的可溶性β1-40/ 1-42的水平。此外，硅藻土降低了MDA含量，并增加了抗氧化酶猫，SOD和NO的活性。基于我们的研究结果，硅蛋白是一种预防Ad相关的β病理学的潜在理想的剂。

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  • 作者

    Bai Dafeng; Jin Ge; Zhang Dajun; Zhao Lini; Wang Mingyue; Zhu Qiwen; Zhu Lin; Sun Yan; Liu Xuan; Chen Xueying; Zhang Liqian; Li Wenbo; Cui Yan;

  • 作者单位

    Eleventh Peoples Hosp Shenyang Dept Pharmacol 103 Hai Tang St Shenyang 110016 Liaoning Peoples;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

    Shenyang Med Coll Dept Pharmacol Key Lab Behav &

    Cognit Neurosci Liaoning Prov 146 Huanghe North;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 人体生理学;
  • 关键词

    Silibinin; Alzheimer's disease; A beta generation; A beta degradation; Antioxidant;

    机译：silibinin;阿尔茨海默病;β生成;β降解;抗氧化剂;

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