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首页> 外文期刊>The Prostate >Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis
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Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis

机译：酒精对实验性自身免疫前列腺炎小鼠模型中慢性盆腔疼痛和前列腺炎症的影响

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Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease of the urogenital system. Alcohol has been reported to be closely related to CP/CPPS. Thus, we intended to verify the role of alcohol in CP/CPPS and determine the underlying mechanism. Methods: We induced experimental autoimmune prostatitis (EAP) mouse model by intradermally injecting a mixture of prostate antigens (PAgs) and complete Freund's adjuvant on days 0 and 28. Mice were treated with alcohol (control-alcohol and EAP-alcohol groups) or vehicle (control-vehicle, and EAP-vehicle groups) from day 32 to 42. Forty-two days after PAg injection, the pathological appearance of the prostate tissues was evaluated, and histological analyses of the prostate were performed. Chronic pelvic pain was assessed by applying von Frey filaments to the lower abdomen. Proinflammatory cytokines were detected by enzyme-linked immunosor-bent assay tests. Then, we explored the effects of the NLRP3 inhibitor MCC950 on chronic pelvic pain and prostatic inflammation in this model.
机译：背景：慢性前列腺炎/慢性盆腔疼痛综合征（CP / CPP）是泌尿生殖系统的普遍存在疾病。据报道，酒精与CP / CPP密切相关。因此，我们打算核实酒精在CP / CPP中的作用，并确定潜在机制。方法：我们通过皮内注射前列腺抗原（PAG）的混合物，在第0天和第28天，用醇（对照 - 醇和EAP-醇基团）或载体处理小鼠，诱导了实验性自身免疫前列腺炎（EAP）小鼠模型。用醇（对照 - 醇和EAP-醇组）或载体处理小鼠（对照车辆和EAP-载体组）从第32天到42.扫描注射后四十二天，评价前列腺组织的病理外观，并进行前列腺的组织学分析。通过将von frey长丝施加到下腹部来评估慢性骨盆疼痛。通过酶联免疫弯曲的测定试验检测促炎细胞因子。然后，我们探讨了NLRP3抑制剂MCC950对该模型中慢性骨盆疼痛和前列腺炎症的影响。

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