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首页> 外文期刊>AIDS care. >What is a missed dose? Implications for construct validity and patient adherence.
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What is a missed dose? Implications for construct validity and patient adherence.

机译：错过的剂量是多少？对结构有效性和患者依从性的影响。

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The construct 'missed dose' is central to many assessments of medication adherence. However, few studies have investigated how patients or clinicians conceptualize missed doses or the extent of the concordance or discordance between clinicians and patients. To address this gap we conducted semi-structured interviews with 45 sero-positive African American adults taking HAART and 17 of their clinicians. Results reveal large variability in missed dose conceptions among both patients and physicians and significant differences between the two groups. Overall, patients reported a stricter definition of missed dose than did clinicians. Fifty-five percent of patients thought that a pill-taking delay of six hours beyond the prescribed dosing time constituted a missed dose, by comparison, only one physician agreed with this assessment. More than one-third of patients thought that the proper response to a missed dose would be to skip it altogether, but only about 12% of clinicians agreed. These findings have implications for the construct validity of self-report measures of adherence, for patient adherence behaviours based on missed dose conceptions and for patient-physician relationships and communication within the clinical environment.
机译：构造“缺失剂量”对于药物依从性的许多评估至关重要。然而，很少有研究调查患者或临床医生如何概念化错过的剂量或临床医生与患者之间一致或不一致的程度。为了弥补这一差距，我们对45名接受HAART的血清阳性非洲裔成年人和17名临床医生进行了半结构化访谈。结果显示，患者和医师之间错过剂量的观念存在很大差异，并且两组之间存在显着差异。总体而言，患者报告的漏诊剂量定义比临床医生更为严格。 55％的患者认为服药延迟超过规定的给药时间六小时构成了错过的剂量，相比之下，只有一名医师同意该评估。超过三分之一的患者认为对漏服的正确反应是完全跳过服药，但只有约12％的临床医生同意。这些发现对依从性自我报告测度的构建效度，基于遗漏剂量概念的患者依从性行为以及临床环境中的患者与医师之间的关系和交流交流具有重要意义。

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