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Acceptability of early anti-retroviral therapy among HIV-infected people in Anhui province in China

机译：中国安徽省艾滋病毒感染者早期抗逆转录病毒治疗的可接受性

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摘要

We investigated the acceptability of early anti-retroviral therapy (ART) among HIV-infected people in Anhui Province, China. A cross-sectional study was conducted in 11 convenience selected cities of Anhui Province from September 2012 to December 2013. Study participants were convenience recruited from local Centers for Disease Control and Prevention when they attended for CD4(+) cell counts testing and HIV counselling. Answers to questionnaires were obtained through face-to-face structured interviews. Factors influencing the acceptability of early ART were identified by multiple logistic regression analysis. A total of 287 HIV-infected people met the criteria and completed the survey. The acceptability of early ART was 65.2%. The results of multiple logistic regression analysis indicated that the acceptability of early ART was associated with the following factors: CD4(+) T cell count (above 750 cells/mu L vs. 350 cells/mu L to 550 cells/mu L: OR = 0.144, P < 0.001), years of HIV diagnosis confirmation (1 year to 5 years vs. <1 year: OR = 0.418, P = 0.005; above 5 years vs. <1 year: OR = 0.160, P < 0.001), whether had sexual behaviour after HIV diagnosis confirmation (yes vs. no: OR = 2.342, P = 0.005) and the awareness of two early ART-related questions (OR = 4.101, P = 0.015; OR = 3.294, P < 0.001). In summary, the present study showed that most HIV-infected people can accept early ART. Early ART interest in Anhui HIV-infected population was high. The awareness of early ART-related knowledge in HIV-infected population was low and should be improved to achieve higher acceptability and keep adherence to early ART for HIV prevention.
机译：我们调查了中国安徽省HIV感染者早期抗逆转录病毒疗法（ART）的可接受性。 2012年9月至2013年12月，在安徽省11个方便选择的城市中进行了横断面研究。研究参与者参加CD4（+）细胞计数测试和HIV咨询时，是从当地疾病控制与预防中心招募的。通过面对面的结构化访谈获得问卷的答案。通过多元逻辑回归分析确定了影响早期抗逆转录病毒疗法可接受性的因素。共有287名HIV感染者符合标准并完成了调查。早期抗逆转录病毒治疗的可接受率为65.2％。多重逻辑回归分析的结果表明，早期抗逆转录病毒疗法的可接受性与以下因素有关：CD4（+）T细胞计数（750个细胞/μL高于350个细胞/μL至550个细胞/μL：或= 0.144，P <0.001），艾滋病毒确诊年限（1年至5年vs. <1年：OR = 0.418，P = 0.005; 5年以上vs. <1年：OR = 0.160，P <0.001） ，在HIV诊断确认后是否有性行为（是或否：OR = 2.342，P = 0.005）以及对两个早期ART相关问题的认识（OR = 4.101，P = 0.015; OR = 3.294，P <0.001） 。总而言之，本研究表明大多数HIV感染者可以接受早期ART。早期对安徽艾滋病毒感染人群的抗逆转录病毒疗法兴趣很高。在感染艾滋病毒的人群中，与抗逆转录病毒有关的早期知识的意识低下，应该提高对抗逆转录病毒疗法的接受程度，并保持对早期抗病毒治疗的依从性。

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