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首页> 外文期刊>AIDS Research and Human Retroviruses >Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA genital shedding in U.S. and Kenyan Women
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Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA genital shedding in U.S. and Kenyan Women

机译：在美国和肯尼亚妇女中，乳杆菌，细菌性阴道病相关细菌与HIV 1型RNA和DNA生殖器脱落之间的相互作用

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Bacterial vaginosis has been associated with genital HIV-1 shedding; however, the effect of specific vaginal bacterial species has not been assessed. We tested cervicovaginal lavage from HIV-1-seropositive women for common Lactobacillus species: L. crispatus, L. jensenii, and seven BV-associated species: BVAB1, BVAB2, BVAB3, Leptotrichia, Sneathia, Megasphaera, and Atopobium spp. using quantitative PCR. We used linear and Poisson regression to evaluate associations between vaginal bacteria and genital HIV-1 RNA and DNA. Specimens from 54 U.S. (310 visits) and 50 Kenyan women (137 visits) were evaluated. Controlling for plasma viral load, U.S. and Kenyan women had similar rates of HIV-1 RNA (19% of visits vs. 24%; IRR=0.95; 95% CI 0.61, 1.49) and DNA shedding (79% vs. 76%; IRR=0.90; 0.78, 1.05). At visits during antiretroviral therapy (ART), the likelihood of detection of HIV-1 RNA shedding was greater with BVAB3 (IRR=3.16; 95% CI 1.36, 7.32), Leptotrichia, or Sneathia (IRR=2.13; 1.02, 4.72), and less with L. jensenii (IRR=0.39; 0.18, 0.84). At visits without ART, only L. crispatus was associated with a lower likelihood of HIV-1 RNA detection (IRR=0.6; 0.40, 0.91). Vaginal Lactobacillus species were associated with lower risk of genital HIV-1 shedding, while the presence of certain BV-associated species may increase that risk.
机译：细菌性阴道病与生殖器HIV-1的脱落有关。但是，尚未评估特定阴道细菌种类的作用。我们测试了来自HIV-1血清反应阳性妇女的宫颈阴道灌洗液中常见的乳杆菌属物种：L.crispatus，L。jensenii和7种与BV相关的物种：BVAB1，BVAB2，BVAB3，Leptotrichia，Sneathia，Megasphaera和Atopobium spp。使用定量PCR。我们使用线性和泊松回归来评估阴道细菌与生殖器HIV-1 RNA和DNA之间的关联。评价了来自54位美国（310位患者）和50位肯尼亚女性（137位患者）的标本。在控制血浆病毒载量方面，美国和肯尼亚妇女的HIV-1 RNA发生率相近（分别为19％vs. 24％; IRR = 0.95; 95％CI 0.61、1.49）和DNA脱落（79％vs. 76％）。内部收益率= 0.90; 0.78，1.05）。在抗逆转录病毒疗法（ART）期间的就诊时，使用BVAB3（IRR = 3.16; 95％CI 1.36，7.32），Leptotrichia或Sneathia（IRR = 2.13; 1.02，4.72）检出HIV-1 RNA的可能性更大，而詹森氏乳杆菌则较少（IRR = 0.39; 0.18，0.84）。在不进行抗逆转录病毒治疗的访视中，仅脆皮乳杆菌与HIV-1 RNA检测的可能性较低相关（IRR = 0.6; 0.40，0.91）。阴道乳杆菌物种与生殖器HIV-1脱落的风险较低，而某些BV相关物种的存在则可能增加该风险。

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