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首页> 外文期刊>The Pediatric infectious disease journal >Enterovirus D68 Causing Acute Respiratory Infection: Clinical Characteristics and Differences With Acute Respiratory Infections Associated With Enterovirus Non-D68
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Enterovirus D68 Causing Acute Respiratory Infection: Clinical Characteristics and Differences With Acute Respiratory Infections Associated With Enterovirus Non-D68

机译：肠道病毒D68导致急性呼吸道感染：临床特征和急性呼吸道感染与肠道病毒非D68相关的临床特征和差异

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Background: Enterovirus (EV) D68 is mainly associated with acute respiratory infection (ARI). Since 2014, when outbreaks in different countries were observed, this emerging virus was considered a potential threat to public health. Methods: During 2015-2017, the presence of enterovirus RNA was investigated in all respiratory samples of children younger than 15 years of age with ARI, obtained for virologic studies in the Pediatric Emergency Care Units and wards of 2 hospitals in Gipuzkoa (Spain), using a commercial multiplex real-time polymerase chain reaction. When enterovirus was detected, a polymerase chain reaction to amplify a specific viral polyprotein (VP1) gene region of EV-D68 was performed. Results: In 2016, EV-D68 circulation was associated to ARI, with the highest incidence in the spring months. EV-D68 was detected in 44 children, mean age 30.1 +/- 31.7 months old, 23 (52.3%) of them females and 17 (38.6%) with underlying respiratory medical conditions. Thirty-two patients (72%) required hospital admission, receiving the discharge diagnosis of recurrent wheezing (37.5%), asthmatic crisis (37.5%) or bronchiolitis (12.5%). Seven children (15.9%) needed the support of the pediatric intensive care unit. When coinfections were excluded, children with EV-D68 infection presented with increased work of breathing, recurrent wheezing or asthmatic crisis, more frequently than those with ARI associated with EV non-D68. Moreover, clinical outcomes (hospitalization, respiratory support) were more severe. All 44 EV-D68 strains detected belonged to lineage B3. Conclusions: EV-D68 circulated widely in Gipuzkoa during 2016 and was associated with severe ARI. In children with severe ARI of unknown etiology, the presence of EV-D68 should be considered.
机译：背景：肠病毒（EV）D68主要与急性​​呼吸道感染（ARI）有关。自2014年以来，观察到不同国家的爆发，这种新兴病毒被认为是对公共卫生的潜在威胁。方法：2015 - 2017年期间，在15岁以下的儿童呼吸样本中对ARI的所有呼吸样本进行了研究，该胃肠病患者，在Gipuzkoa（西班牙）的2家医院的病毒学研究中获得了病毒学研究，使用商业多重实时聚合酶链反应。检测到肠道病毒时，进行聚合酶链反应，以扩增EV-D68的特异性病毒多蛋白（VP1）基因区。结果：2016年，EV-D68流通与ARI相关，春季最高发病率。 EV-D68在44名儿童中检测到，平均年龄为30.1 +/- 31.7个月，其中23（52.3％），女性和17名（38.6％），具有潜在的呼吸系统医疗条件。 32例患者（72％）所需医院入院，接受复发性喘息（37.5％），哮喘危机（37.5％）或支气管炎（12.5％）的排放诊断。七个孩子（15.9％）需要对儿科重症监护病房的支持。当被排除繁殖时，患有EV-D68感染的儿童随着呼吸，复发性喘息或哮喘危机的增加而不是与EV非D68相关的ARI。此外，临床结果（住院，呼吸促进剂）更严重。检测到的所有44 eV-D68菌株属于谱系B3。结论：2016年在Gipuzkoa中广泛传播的EV-D68，与严重的ARI有关。在未知病因的严重ARI的儿童中，应考虑EV-D68的存在。

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