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Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV

机译：饮酒与艾滋病毒感染者的病情发展和心理健康的纵向关联

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We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV. The study included 871 women with HIV who were recruited from 1993-1995 in four US cities. The participants had physical examination, medical record extraction, and venipuncture, CD4+ T-cell counts determination, measurement of depression symptoms (using the self-report Center for Epidemiological Studies-Depression Scale), and alcohol use assessment at enrollment, and semiannually until March 2000. Multilevel random coefficient ordinal models as well as multilevel models with joint responses were used in the analysis. There was no significant association between level of alcohol use and CD4+ T-cell counts. When participants were stratified by antiretroviral therapy (ART) use, the association between alcohol and CD4 + T-cell did not reach statistical significance. The association between alcohol consumption and depression was significant (p < 0.001). Depression had a significant negative effect on CD4+ T-cell counts over time regardless of ART use. Our findings suggest that alcohol consumption has a direct association with depression. Moreover, depression is associated with HIV disease progression. Our findings have implications for the provision of alcohol use interventions and psychological resources to improve the health of women with HIV.
机译：我们评估了饮酒与抑郁症之间的关系，以及它们对感染艾滋病毒的女性的艾滋病毒感染进程的影响。该研究包括从1993年至1995年在美国四个城市招募的871名艾滋病毒女性。参加者进行了体格检查，病历提取和静脉穿刺，CD4 + T细胞计数测定，抑郁症状的测量（使用流行病学自我报告中心-抑郁量表）以及入学时的酒精使用评估，每半年一次，直到3月2000年。在分析中使用了多级随机系数序数模型以及具有联合响应的多级模型。饮酒水平与CD4 + T细胞计数之间无显着关联。当参与者通过抗逆转录病毒疗法（ART）进行分层时，酒精与CD4 + T细胞之间的关联并未达到统计学意义。饮酒与抑郁之间的相关性显着（p <0.001）。无论使用ART为何，抑郁症都会对CD4 + T细胞计数产生明显的负面影响。我们的发现表明，饮酒与抑郁症有直接关系。而且，抑郁症与HIV疾病的发展有关。我们的发现对提供饮酒干预措施和心理资源以改善艾滋病毒女性健康具有重要意义。

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