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Youth, unemployment, and male gender predict mortality in AIDS patients started on HAART in Nigeria.

机译：青年，失业和男性性别预测了尼日利亚HAART上开始的艾滋病患者的死亡率。

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摘要

This retrospective study identifies risk factors for mortality in a cohort of HIV-positive adult patients treated with highly active antiretroviral therapy (HAART) in Jos, Nigeria. We analyzed clinical data from a cohort of 1552 patients enrolled in a HIV/acquired immune deficiency syndrome treatment program and started on HAART between December 2004 and 30 April 2006. Death was our study endpoint. Patients were followed in the study until death, being lost to follow-up, or the end of data collection, 1 December 2006. Baseline patient characteristics were compared using Wilcoxon Rank Sum Test for continuous variables and Pearson Chi-Square test for categorical variables to determine if certain demographic factors were associated with more rapid progression to death. The Cox proportional hazard multivariate model analysis was used to find risk factors. As of 1 December 2006, a total of 104 cases progressed to death. In addition to the expected association of CD4 count less than 50 at initiation of therapy and active tuberculosis with mortality, the patient characteristics independently associated with a more rapid progression to death after initiation of HAART were male gender, age less than 30 years old, and unemployment or unknown occupation status. Future research is needed to identify the confounding variables that may be amenable to targeted interventions aimed at ameliorating these health disparities.
机译：这项回顾性研究确定了在尼日利亚乔斯接受高活性抗逆转录病毒治疗（HAART）的一组HIV阳性成年患者死亡的危险因素。我们分析了2004年12月至2006年4月30日期间参加HIV /获得性免疫缺陷综合症治疗计划并从HAART开始的1552名患者的临床资料。死亡是我们的研究终点。对患者进行研究，直至死亡，失去随访或数据收集结束（2006年12月1日）。使用Wilcoxon Rank Sum检验（连续变量）和Pearson Chi-Square检验（分类变量）比较基线患者特征。确定某些人口统计学因素是否与更快的死亡进展有关。使用Cox比例风险多元模型分析来查找风险因素。截至2006年12月1日，共有104例死亡。除了预期开始治疗时CD4计数少于50和活动性结核与死亡率的相关性外，患者的特征还包括男性，年龄小于30岁的患者，以及开始进行HAART后死亡更快的进展。失业或身份不明的职业。需要进行进一步的研究，以确定可能适用于旨在改善这些健康差异的针对性干预措施的混杂变量。

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